The 6q25.1 rs2046210 polymorphism is associated with an elevated susceptibility to breast cancer: A meta ‐analysis of 261,703 subjects

This is so far the most comprehensive evidence ‐based meta‐analysis on rs2046210 polymorphism and individual susceptibility to BC. Our findings indicated that rs2046210 polymorphism may serve as a potential genetic biomarker of BC in both Asians and Caucasians. AbstractBackgroundSeveral genome ‐wide association studies already explored the associations between 6q25.1 rs2046210 polymorphism and breast cancer (BC), but the results of these studies were not consistent. Thus, we conducted a meta‐analysis of relevant studies to better analyze the effects of rs2046210 polymorphism on indivi dual susceptibility to BC.MethodsPubMed, Web of Science, and Embase were searched for eligible studies. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated.ResultsTotally 21 studies with 261,703 subjects were analyzed. A significant association with BC was observed for the rs2046210 polymorphism in GG versus GA +AA (dominant comparison,p 
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: ORIGINAL ARTICLE Source Type: research

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Abstract Discriminative identification of homologous miRNAs in miRNA family with high specificity and sensitivity is crucial for accurate classification, diagnosis and prognosis of breast cancer. Herein, we report a reliable, sensitive, and selective assay by coupling fluorescence resonance energy transfer (FRET) with cascade signal amplification. The strategy is developed by designing two programmable DNA probes that can be triggered to shift from "off" to "on" state in a cascade hybridization reaction in the presence of target miRNA let-7a, leading to the generation of an amplified signal. Th...
Source: Analytica Chimica Acta - Category: Chemistry Authors: Tags: Anal Chim Acta Source Type: research
Cancer Biotherapy and Radiopharmaceuticals, Ahead of Print.
Source: Cancer Biotherapy and Radiopharmaceuticals - Category: Cancer & Oncology Authors: Source Type: research
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Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Conditions breast cancer Oncology/Hematology Source Type: blogs
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Source: Life Sciences - Category: Biology Source Type: research
Conditions:   Breast Cancer Metastatic;   Bone Metastases Interventions:   Other: Bone metastasis;   Other: Breast cancer metastatic to bone Sponsor:   Istituto Ortopedico Galeazzi Not yet recruiting
Source: - Category: Research Source Type: clinical trials
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Source: Pathology Research and Practice - Category: Pathology Source Type: research
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Source: Pathology Research and Practice - Category: Pathology Source Type: research
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Source: Best Practice and Research Clinical Obstetrics and Gynaecology - Category: OBGYN Source Type: research
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Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
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Source: Immunological Investigations - Category: Allergy & Immunology Tags: Immunol Invest Source Type: research
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