Comparable rates of simulator sickness in Huntington's disease and healthy individuals - Jacobs M, van der Zwaan KF, Hart EP, Groeneveld GJ, Roos RAC.

OBJECTIVE Investigating driving competence with a simulator provides a controlled setting and has a high reproducibility. In addition, there is less risk of physical harm compared to on-road tests. A disadvantage of using simulators is the occurrence of s...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

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Case could result in shift in confidentiality rules Related items fromOnMedica Men ’s dementia risk higher after androgen deprivation therapy Patients with genetic disease history face discrimination GMC stresses duty to report poor care NICE calls for consistent clinical and social care in cerebral palsy Does evidence support doctors recommending acupuncture for pain?
Source: OnMedica Latest News - Category: UK Health Source Type: news
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In this study, we used a quantitative model of compensation, known as the CRUNCH (Compensation-Related Utilization of Neural Circuits Hypothesis), to explicitly characterise compensation in pre-HD. The assumption of the model is that fMRI activity increases as task difficulty increases (compensatory effect). However, when individuals reach the ‘CRUNCH’ point, where task difficulty exceeds their neural resources, fMRI activity and performance declines. We acquired fMRI data (n = 15 pre-HD; n = 15 controls) during performance of an fMRI visuospatial working memory task with low, intermediate-1, intermedia...
Source: Neuropsychologia - Category: Neurology Source Type: research
CONCLUSIONS: In this review, biological and chemical knowledge of melatonin, its experimental effects, and the clinical impact on patients with neurological disorders were described. According to all of the beneficial results obtained from experimental and clinical trials, melatonin may have a prophylactic and therapeutic effect on neurological diseases. Strong collaboration between neurologists and health service policy makers is needed to encourage use of melatonin in the patients suffering from neurological diseases. Melatonin may be the solution we have been looking for. PMID: 31718830 [PubMed - as supplied by publisher]
Source: Revue Neurologique - Category: Neurology Tags: Rev Neurol (Paris) Source Type: research
In conclusion, Vilda purveyed significant anti-Huntington effect which may be mediated, at least in part, via activation of GLP-1/PI3K/Akt pathway in 3NP rat model.
Source: Neurotherapeutics - Category: Neurology Source Type: research
Huntington ’s Disease (HD) is a fatal neurodegenerative disorder caused by a CAG repeat expansion, resulting in a mutant huntingtin protein. While it is now clear that astrocytes are affected by HD and signific...
Source: Epigenetics and Chromatin - Category: Genetics & Stem Cells Authors: Tags: Research Source Type: research
CONCLUSION: Various formulations of lithium have potential for treating neurodegenerative brain diseases but further study on their pharmacokinetics will be required in order to determine the optimal formulation, dosage and route of administration. PMID: 31724518 [PubMed - as supplied by publisher]
Source: CNS and Neurological Disorders Drug Targets - Category: Drugs & Pharmacology Authors: Tags: CNS Neurol Disord Drug Targets Source Type: research
AbstractPurpose of ReviewThere is emerging evidence that music therapy and other methods using music and rhythm may meaningfully improve a broad range of symptoms in neurological and non-neurological disorders. This review highlights the findings of recent studies utilizing music and rhythm-based interventions for gait impairment, other motor symptoms, and non-motor symptoms in Parkinson disease (PD) and other movement disorders. Limitations of current studies as well as future research directions are discussed.Recent FindingsMultiple studies have demonstrated short-term benefits of rhythmic auditory stimulation on gait pa...
Source: Current Neurology and Neuroscience Reports - Category: Neuroscience Source Type: research
Researchers here demonstrate a proof of principle for an interesting approach to tackling the aggregation of damaged, altered, or misfolded proteins that is a feature of most neurodegenerative conditions. They target the mutant huntingtin protein, which is probably an easier task than targeting, say, a misfolded protein with a normal sequence. The basic idea is to deploy a linking molecule that binds to the problem protein with high specificity, and also binds to an essential component of autophagy - in this case LC3B, involved in the generation of autophagosomes responsible for carrying materials to lysosomes. This ensure...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
One of the most important challenges facing medical science is to better understand the cause of neuronal pathology in neurodegenerative diseases. Such is the case for Huntington’s disease (HD), a genetic disorder primarily caused by a triplet expansion in the Huntingtin gene (HTT). Although aberrant HTT is expressed from embryogenesis, it remains puzzling as to why the onset of disease symptoms manifest only after several decades of life. In the present study, we investigated the possibility of microbial infection in brain tissue from patients with HD, reasoning that perhaps mutated HTT could be deleterious for immu...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
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