PBPK Modeling of Coproporphyrin I as an Endogenous Biomarker for Drug Interactions Involving Inhibition of Hepatic OATP1B1 and OATP1B3

In conclusion, PBPK modeling of CP ‐I supports dynamic prediction of OATP1B‐mediated DDIs.

Source: CPT: Pharmacometrics and Systems Pharmacology - November 29, 2018 Category: Drugs & Pharmacology Authors: Takashi Yoshikado, Kota Toshimoto, Kazuya Maeda, Hiroyuki Kusuhara, Emi Kimoto, A. David Rodrigues, Koji Chiba, Yuichi Sugiyama Tags: Article Source Type: research