Psoriasis therapy and aortic inflammation - translating statistical to clinical significance.

Psoriasis therapy and aortic inflammation - translating statistical to clinical significance. Dermatol Online J. 2018 Sep 15;24(9): Authors: Kazemi A, Cline A, Cardwell LA, Feldman SR Abstract Psoriasis patients are known to have comorbid aortic vascular inflammation, which is one of the leading causes of cardiovascular morbidity and mortality in this population. Many studies report statistically significant improvements in aortic vascular inflammation after use of tumor necrosis factor inhibitors or interleukin-12/23 antagonists. However, the clinical significance in reduction of adverse cardiovascular events in psoriatic patients owing to biologic therapy has not been examined. Regardless of clinically significant cardiovascular benefits, dermatologists should continue to treat psoriasis patients optimally to mitigate the unfavorable effect this disease has on quality of life. PMID: 30677825 [PubMed - in process]
Source: Dermatol Online J - Category: Dermatology Authors: Tags: Dermatol Online J Source Type: research