Tumour heterogeneity in triplet-paired metastatic tumour tissues in metastatic renal cell carcinoma: concordance analysis of target gene sequencing data.

CONCLUSIONS: The study provides reference information on the genetic alterations at various organ sites and the multi-heterogeneity of mRCC tissues. The concordance of pathogenic gene alterations within tissues was not high, and approximately half of the patients showed no pathogenic gene alterations at all. PMID: 30409839 [PubMed - indexed for MEDLINE]

https://www.ncbi.nlm.nih.gov/pubmed/30409839?dopt=Abstract

Source: Clinical Prostate Cancer - January 28, 2019 Category: Cancer & Oncology Authors: Kim SH, Park WS, Chung J Tags: J Clin Pathol Source Type: research