Cutaneous lichen planus: A systematic review of treatments

Journal of Dermatological Treatment, Ahead of Print.
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: article Source Type: research

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Authors: DENTAL SUPPLEMENT, Romano A, Contaldo M, Della Vella F, Russo D, Lajolo C, Serpico R, Di Stasio D Abstract Photodynamic Therapy (PDT) is a minimally invasive approach that has shown promising results in management of oral, head and neck lesions. PDT can be used alone or in combination with other conventional treatments (surgery, chemotherapy, radiotherapy). Oral Lichen Planus (OLP) is a mucosal and cutaneous chronic disease characterized by an autoimmune insult of basal keratinocytes. We aim to evaluate the feasibility of topical toluidine blue-mediated PDT for the treatment of oral cavity multifocal homog...
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
Condition:   Oral Lichen Planus Intervention:   Drug: Co-Enzyme Q10 mucoadhesive tablets Sponsor:   Cairo University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Paras Ahmad, Usman Akhtar, Ahmed Chaudhry, Usman Rahid, Sarmad Saif, Jawaad Ahmed AsifEuropean Journal of General Dentistry 2019 8(3):55-62 Oral health is a cardinal element of nutritional as well as systemic well-being and plays a substantial part in sustaining optimum general health condition. Various factors influence oral health including metabolic diseases such as endocrine (diabetes mellitus [DM]), hematological, gastrointestinal, cutaneous, and neurological diseases. The intent of this review is to accentuate the correlation between DM and oral disorders, like those upsetting oral mucosa and supporting tissues. A r...
Source: European Journal of General Dentistry - Category: Dentistry Authors: Source Type: research
PMID: 31489984 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research
Conclusion: Dermoscopy is useful in differentiating HLP and PN. Blue-gray globules, comedo-like openings, and follicular plugging were specific for HLP. Pearly white areas with white starburst pattern and red dots and globules were the specific findings in PN.
Source: Indian Journal of Dermatology - Category: Dermatology Authors: Source Type: research
Conclusion: This study is useful in understanding the various clinical patterns of postmenopausal dermatoses and thereby help the physician, dermatologist, and gynecologist to effectively manage the conditions.
Source: Indian Journal of Dermatology - Category: Dermatology Authors: Source Type: research
In this study, we aimed to assess the diagnostic accuracy of ex vivo CLSM in identifying histopathological features and basal membrane (BM) fluorescence with fibrinogen in lichen planus (LP) and as lupus band test in cutaneous lupus erythematosus (LE), as well as to compare its diagnostic accuracy with conventional histopathology and direct immunofluorescence (DIF) microscopy.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research and Epidemiology Source Type: research
Lichen planus (LP) is a chronic inflammatory mucocutaneous disease wherein cell mediated immunity plays a pivotal role. Regarding its pathogenesis, several hypotheses have been  suggested. Recent studies have focused on the role of oxidative stress. 8-hydroxy-2′-deoxyguanosine (8-OHdG) is the major free radical resulted from the action of oxidative stress on nuclear and mitochondrial DNA. Considering the association of LP with hepatitis C virus (HCV) infection, the aim of our study is to evaluate 8-OHdG as an oxidative stress marker and observe the influence of HCV in LP patients.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research and Epidemiology Source Type: research
Chronic Pruritus (CP), a primary symptom in dermatological conditions, is often intractable and strongly impacts patient quality of life. Expression of CP-related biomarkers, Oncostatin M receptor β (OSMRβ) and Interleukin-31 (IL-31), were assessed in these CP-presenting diseases: Chronic Idiopathic Pruritus (CIP), Chronic Idiopathic Urticaria (CIU), Lichen Planus (LP), and Lichen Simplex Chronicus (LSC) and correlated with clinical features. mRNA and protein expression from archived skin s amples from disease and non-pruritic control patients were analyzed by RNAscope and Immunohistochemistry (IHC) methods for I...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Innate Immunity and Inflammation Source Type: research
There are several studies showing the link between lichen planus (LP) and hepatitis C virus (HCV) infection. However, the mechanisms involved are incompletely elucidated. Investigating the implication of oxidative stress could shed some light on LP pathogenesis and its link with HCV infection. We have enrolled 12 LP patients with HCV infection (group A), 12 patients without LP, with HCV infection (group B), 31 LP patients without HCV infection (group C), and 26 healthy subjects (control group - group D).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Innate Immunity and Inflammation Source Type: research
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