Differentiation and proliferation of intestinal stem cells and its underlying regulated mechanisms during weaning.

Differentiation and proliferation of intestinal stem cells and its underlying regulated mechanisms during weaning. Curr Protein Pept Sci. 2019 Jan 24;: Authors: Chen X, Yang Z, Hu H, Duan W, Wang A, Dong Y, Gao W, Deng S, Cheng B, Li J, Sun N, Cheng Z, Guo W, Li Y, Gao Y Abstract Weaning is a stressful event associated with gastrointestinal disorders and increased disease susceptibility. Many studies have reported the changes happened in the gut of various mammals such as pigs and rats after weaning. These findings suggest that the development of intestinal tract mainly is affected at the time of weaning through interfering in the differentiation and proliferation of intestinal stem cells. Weaning stress stimulates the rapid differentiation and proliferation of intestinal stem cells in order to adjust to changes caused by weaning, which are mainly manifested as deeper crypt depth and intestine decreased villus height. However, the accelerated cellular process may lead to an increase in the proportion of immature intestinal epithelial cells and goblet cells, which affect intestinal permeability and reduce the gut-barrier function against toxins and pathogens. This review briefly describes the effects of Corticotrophin-releasing factor (CRF), epidermal growth factor (EGF) and polyamines on the differentiation and proliferation of intestinal stem cells after weaning and discusses its possible underlying regulatory mechanisms. Firstly, w...
Source: Current Protein and Peptide Science - Category: Biochemistry Authors: Tags: Curr Protein Pept Sci Source Type: research