The optimal treatment for improving the cognitive function in elder people diagnosed with mild cognitive impairment incorporating Bayesian network meta-analysis and systematic review.

This study focuses on three cognitive interventions referred from Clare and Woods, that is, Cognitive stimulation(CS), Cognitive training(CT) and Cognitive rehabilitation(CR). Our Network meta-analysis(NMA) is aimed at comparing them with each other for evaluating the optimal cognitive intervention to help elderly adults with MCI to improve their cognitive function. We applied extensive strategies on preliminary literature collection to identify relevant randomized controlled trials (RCTs) which scrupulously compare any of these cognitive interventions with each other or instead with control groups such as with placebo or non-active groups as monotherapy in treatment with elder patients diagnosed primarily with MCI in accordance with the Petersen's criterion. Our NMA of cognitive interventions for patients diagnosed with MCI appraised the relative effectiveness of cognitive interventions across trials simultaneously, our study is attempted to summarize available data to suggest that CS (Mean difference [MD] = 0.95, 95% confidence interval [CI]:0.27, 1.70) and CT (MD = 0.70, [CI]:0.11,1.30) were significantly beneficial to help MCI patients to improve their cognition status while CR gets the lowest rank. There's no previous study which has solved the problem of which cognitive intervention is relatively the best intervention for MCI, our study suggested CS was most likely to be the best treatment for improving the cognitive ability of them. PMID: 30682429 [PubM...
Source: Ageing Research Reviews - Category: Genetics & Stem Cells Authors: Tags: Ageing Res Rev Source Type: research