siRNA against TSG101 reduces proliferation and induces G0/G1 arrest in renal cell carcinoma - involvement of c-myc, cyclin E1, and CDK2.

Conclusions: TSG101 promotes proliferation of RCC cells. This positive effect on tumor growth involves activation of c-myc and cyclin E1/CDK2 and their effect on cell cycle distribution.
PMID: 30675171 [PubMed - in process]

Source: Cellular and Molecular Biology Letters - January 26, 2019 Category: Biochemistry Authors: Xu C, Zheng J Tags: Cell Mol Biol Lett Source Type: research