Differential expression of TGFβ1 is associated with fetal regeneration after myocardial infarction

ConclusionsTGFβ1 is increased in adult infarcts compared to regenerative, fetal infarcts following MI. While treatment of fetal cardiac fibroblasts with TGFβ1 conveys an adult phenotype, inhibition of TGFβ1 conveys a fetal phenotype to adult cardiac fibroblasts. Decreasing TGFβ1 following MI may facilitate myocardial regeneration by ‘fetalizing’ the otherwise fibrotic, adult response to MI.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research