Analysis of the protective effects of γ-aminobutyric acid during fluoride-induced hypothyroidism in male Kunming mice.

Analysis of the protective effects of γ-aminobutyric acid during fluoride-induced hypothyroidism in male Kunming mice. Pharm Biol. 2019 Dec;57(1):29-37 Authors: Yang H, Xing R, Liu S, Yu H, Li P Abstract CONTEXT: Compounds to treat hypothyroidism in the absence of cardiac side effects are urgently required. In this regard, γ-aminobutyric acid (GABA) has gained interest due to its anti-anxiolytic, antihypertensive and antioxidant properties, and reported benefits to the thyroid system. OBJECTIVE: We investigated the ability of GABA to ameliorate fluoride-induced thyroid injury in mice, and investigated the mechanism(s) associated with GABA-induced protection. MATERIALS AND METHODS: Adult male Kumning mice (N = 90) were exposed to NaF (50 mg/kg) for 30 days as a model of hypothyroidism. To evaluate the effects of GABA administration, fluoride-exposed mice received either thyroid tablets, or low (25 mg/kg), medium (50 mg/kg) or high (75 mg/kg) concentrations of pure GABA orally for 14 days groups (N = 10 each). The effects of low (50 mg/kg); medium (75 mg/kg) and high (100 mg/kg) concentrations of laboratory-separated GABA were assessed for comparison. Effects on thyroid hormone production, oxidative stress, thyroid function-associated genes, and side-effects during therapy were measured. RESULTS: GABA supplementation in fluoride-exposed mice si...
Source: Pharmaceutical Biology - Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

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ConclusionThe treatment of choice for hypothyroidism in Sweden is L-T4 tablets. Combination therapy with L-T4+L-T3 tablets was considered for patients with persistent symptoms despite biochemical euthyroidism. Soft-gel capsules and liquid solutions of L-T4 were infrequently prescribed. Swedish endocrinologists’ deviation from endocrine society guidelines merits further study.
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Without any doubt, high dose radiation exposure can induce hypothyroidism. However, there are open questions related to the mechanisms of its induction, corresponding dose thresholds and possible countermeasures. Therefore, this review addresses the aetiology, prevention and therapy of radiation induced hypothyroidism. External beam radiotherapy with several 10 Gy to the head and neck region and radioiodine therapy with several 100 Gy thyroid absorbed dose can destroy the thyroid gland and can induce autoantibodies against thyroid tissue. According to recent literature, clinical hypothyroidism is observed at threshol...
Source: Journal of Radiological Protection - Category: Physics Authors: Source Type: research
Condition:   Quality of Life Among Hypothyroid Patients Intervention:   Other: assessment of quality of life using questionnaire Sponsor:   Assiut University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
WINTER has arrived and with it icy cold temperatures. While the heating may be working hard in our homes - some people can struggle to keep their feet warm. So why are your feet always cold? Here are five key reasons, and when you should see your doctor.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
CONCLUSION: The treatment of choice for hypothyroidism in France is LT4. LT3-based therapy is considered by some physicians in case of persistent symptoms of hypothyroidism despite normal TSH level. A significant proportion of respondents (66.0%) would consider treating euthyroid patients, contrary to the present state of knowledge. These outdated practices should be addressed by professional bodies such as the FES.PMID:34861221 | DOI:10.1016/j.ando.2021.11.002
Source: Annales d'Endocrinologie - Category: Endocrinology Authors: Source Type: research
CONCLUSION: Patients with severe CTS are more inclined toward surgery than those with moderate CTS. Controlling BMI and preventing vitamin B12 deficiency may help keep alleviate complaints related to CTS with less invasive treatment modalities.PMID:34859834 | DOI:10.5137/1019-5149.JTN.34519-21.2
Source: Turkish Neurosurgery - Category: Neurosurgery Authors: Source Type: research
Conclusions: Although selfie is considered a modern-day lifestyle-induced psychiatric illness, it can inadvertently help in picking up thyroid diseases in earlier stages.
Source: Annals of African Medicine - Category: African Health Authors: Source Type: research
ConclusionAlthough we found a significant association between HT and some types of TCs, High RoB studies, high level of heterogeneity, and the limited number of well-designed prospective studies, suggested the need for more studies to reach more reliable evidence.
Source: Thyroid Research - Category: Endocrinology Source Type: research
In this study, we examined the effect of T3 administration on DNA fragmentation induced by neuronal death and the activation of inflammatory cells such as astrocytes and microglia in the hippocampus following GCI. The content of nucleosomes generated by DNA fragmentation in the hippocampus was increased by GCI and further increased by T3 administration. The protein expression levels of glial fibrillary acidic protein (GFAP), an astrocytic marker, and Ionized calcium binding adaptor protein 1 (Iba1), a microglial marker, in the hippocampus were also increased by GCI and further increased by T3 administration. The levels of ...
Source: Biological and Pharmaceutical Bulletin - Category: Drugs & Pharmacology Authors: Source Type: research
Endokrynol Pol. 2021 Dec 2. doi: 10.5603/EP.a2021.0093. Online ahead of print.ABSTRACTHypothyroidism is an endocrine disorder whose management raises many challenges in clinical practice. Its standard treatment is levothyroxine (LT4). The goal of the treatment is to normalize signs and symptoms, as well as to achieve thyroid-stimulating hormone (TSH) concentrations within the reference range, on an individual basis. It is known that 5-10 % of hypothyroid patients remain to be symptomatic, despite achieving the target TSH levels, which, in turn, affects their quality of life. After ruling out other causes of non-thyroid ori...
Source: Endokrynologia Polska - Category: Endocrinology Authors: Source Type: research
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