Propolis nanoparticles prevent structural changes in human hemoglobin during glycation and fructation
Publication date: Available online 23 January 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Fatemeh Kazemi, Adeleh Divsalar, Ali Akbar Saboury, Arefeh SeyedarabiAbstractNowadays diabetes, as a metabolic disorder, is increasing at an alarming rate. Glycation and production of advanced glycation end products (AGEs) is the most important factor involved in diabetic complications. Due to the side effects of synthetic drugs, the demand for natural anti-diabetic herbal medicines has increased. Propolis is a natural and resinous material, which iscollected by honeybees. Due to the impact of nanotechnology in medicine and the advantageous role of nanoparticles in treatment, nano-propolis particles (PNP) were prepared.The anti-glycation effect of PNP at various concentrations was investigated on human hemoglobin (Hb) glycation and fructation and compared with aspirin as a common anti-glycation agent using glycation specific AGE fluorescence, AGE-specific absorbance and circular dichroism (CD) methods. Fluorescence spectroscopy results showed that PNP inhibited the formation of AGEs in Hb glycation and fructation by glucose and fructose, respectively. CD results revealed that PNP caused an increase in Hb beta-sheet content while decreasing the alpha helical content. Additionally, the results of UV-Vis spectroscopy and fluorescence emission of heme degradation products revealed the protective effect of PNP on heme during glycation and fructation of human Hb. It is notable...
CONCLUSION: The genotypic distribution of Chr-11 tRNA-Lys-CUU in our population was consistent to that reported by others. This gene failed as a marker for T2DM predisposition. PMID: 30882233 [PubMed - as supplied by publisher]
Brief ReportBarbara Daly, Bruce Arroll, Nicolette Sheridan, Timothy Kenealy, Robert Scragg,Primary Health Care Research&Development,Volume 17 Issue 05, pp 524-529Abstract
Learn how to successfully manage thyrotoxicosis -- from preconception to the postpartum period.Endocrine Practice
To what extent is sex hormone signaling involved in the development of gender dysphoria?Journal of Clinical Endocrinology &Metabolism
Authors: Laucyte-Cibulskiene A, Vickiene A, Ryliskyte L, Badariene J, Rimsevicius L, Miglinas M Abstract PURPOSE: The study was designed to evaluate clinical and laboratory determinants pulse wave velocity (PWV) ratio in women at the age of 50-65 years without overt cardiovascular disease but having elevated cardiovascular risk, such as hypertension, obesity, diabetes and hypercholesterolemia. MATERIALS AND METHODS: We analyzed data from 1170 women enrolled in the national-wide primary prevention program. Univariate and multivariate linear regression analysis was used to establish independent risk factors in gr...
Journal Name: Drug Metabolism and Personalized Therapy Issue: Ahead of print
Jianping Chen, Lin Zheng, Zhaoliu Hu, Fochang Wang, Shiying Huang, Zhonggui Li, Ping Zheng, Shangbin Zhang, Tiegang Yi, Huilin Li
A red spot on the eye is usually a subconjunctival hemorrhage that will heal over time without treatment. It can also be due to diabetes complications. Learn more about the causes and treatments here.
ConclusionsThis methodology makes possible the precise, simultaneous and reliable analysis of podocalyxin and podocin levels, and offers a valuable tool for the evaluation of podocyturia.Graphical abstract
Julie Dao, Catherine Spooner, Winston Lo, Mark F. Harris