Comparison of perinatal outcomes following blastocyst stage vs cleavage stage embryo transfer: 10 years data analysis from a single center

Publication date: Available online 25 January 2019Source: Reproductive BioMedicine OnlineAuthor(s): Wenhao Shi, Wei Zhang, Na Li, Xia Xue, Chen Liu, Pengfei Qu, Juanzi Shi, Chen HuangAbstractResearch QuestionIs there a risk of perinatal outcomes and congenital malformations after blastocyst transfer compared with cleavage stage embryo transfer in IVF?DesignThis was a retrospective cohort analysis form an ART center in a public hospital of China. All conceived women (15,254) and newborns (16,213) from IVF/ICSI cycles with cleavage embryo transfer or blastocyst transfer were included during 2006–2015. Outcome measurements included congenital malformations, preterm birth, low birth weight, small for gestational age and large for gestational age.ResultsAfter logistic regression analysis, there was a sex ratio imbalance toward males in the neonates after blastocyst transfer (P=0.001; Adjusted OR, 1.17; 95%CI 1.07∼1.30). But beyond that, there were no differences of miscarriage, ectopic pregnancy, stillbirth, very preterm birth rate (
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research

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Abstract Objective: To investigate the feasibility and clinical outcome of the all-blastocyst-culture and single blastocyst transfer strategy in women aged ≥35 years. Methods: A retrospective analysis of patients aged ≥35 years undergoing IVF/ICSI was performed from January 2017 to April 2019 in the reproductive center of the Second Affiliated Hospital of Wenzhou Medical University. A total of 155 cases treated with ovarian hyperstimulation by prolonged protocol and implemented single (84 cases) or double (71 cases) blastocyst transfer were collected. Then, patients were further divided into
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
This study aimed to investigate the effect of the detail type of chromosomal polymorphisms (1/9/16qh+/ −, D/G group polymorphisms, and inv(9)) on the IVF-ET outcomes.MethodsA total of 1335 infertile couples undergoing IVF/ICSI were enrolled and comprehensively analyzed the correlation between three detail types of chromosomal polymorphisms (1/9/16qh+/ −, D/G group polymorphisms, and inv(9)) and the outcome of IVF/ICSI embryo transfer. The fertilized rate, cleaved embryo rate, good-quality embryo rate, clinical pregnancy rate, implantation rate, and early stage miscarriage rate were compared between the chromoso...
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
ConclusionThis study concurs with the recent data suggesting that employing ICSI solely for teratospermia is unnecessary. This may allow clinics to decrease ICSI rates without sacrificing success rates, leading to lower cost and risk associated with treatment.
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
ConclusionWithin the limits of the small sample size, our results suggest that the aneuploidy and delivery rates of the blastocysts derived from 1PN zygotes are the same as those derived from 2PN zygotes. Blastocysts derived from 1PN zygotes may be used clinically and could increase the chance of pregnancy.
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
ConclusionsThe study highlights the importance of sperm quality for the efficacy of assisted reproduction treatments. This influence may remain relatively cryptic in association with normal or high ovarian response, but emerge decisively in cases of reduced ovarian response, suggesting a relationship between ovarian response and oocyte ability to compensate for paternal-derived deficiencies.
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
This study examined 769 patients with nonobstructive azoospermia who underwent 347 cycles of micro-TESE-ICSI. Patients with azoospermia were classified into Group A (Klinefelter syndrome, n = 284, 125 cycles), Group B (azoospermia Y chromosome factor c [AZFc] microdeletion, n = 91, 64 cycles), Group C (cryptorchidism, n = 52, 39 cycles), Group D (previous mumps and bilateral orchitis, n = 23, 23 cycles), and Group E (idiopathic azoospermia, n = 319, 96 cycles). Clinical characteristics, SRR, embryonic development, and pregnancy outcomes of the patients were compared between all groups. Patients in Group D had the highest a...
Source: Asian Journal of Andrology - Category: Urology & Nephrology Authors: Tags: Asian J Androl Source Type: research
Conditions:   Infertility;   Recurrent Implantation Failure;   Recurrent Miscarriage Intervention:   Sponsor:   Peking University Third Hospital Not yet recruiting
Source: - Category: Research Source Type: clinical trials
CONCLUSIONS: The current evidence from randomised controlled trials does not support or refute the clinical use of intracytoplasmic sperm injection (intracytoplasmic morphologically selected sperm injection (IMSI). We are very uncertain of the chances of having a live birth and of the risk of having a miscarriage. We found very low-quality evidence that IMSI may increase chances of a clinical pregnancy, which means that we are still very uncertain about any real difference. We did not find any trials reporting on the risk of congenital abnormalities. Well-designed and sufficiently powered trials are still required. PM...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
CONCLUSIONS: While avoiding unnecessary embryo transfers and miscarriages are important goals, patients and doctors need to be aware of the high cost implications of applying PGT-A using aCGH on polar bodies. FUNDING: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. The ESTEEM study was funded by the European Society for Human Reproduction and Embryology. Illumina provided microarrays and other consumables necessary for aCGH testing of polar bodies. PMID: 31930663 [PubMed - as supplied by publisher]
Source: BJOG : An International Journal of Obstetrics and Gynaecology - Category: OBGYN Authors: Tags: BJOG Source Type: research
ConclusionsAOA was able to “rescue” the poor reproductive outcomes in certain types of infertile couples with history of failure pregnancy.
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
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