Physical Activity and Sex Hormone-Binding Globulin in Older Adults.

Physical Activity and Sex Hormone-Binding Globulin in Older Adults. J Aging Phys Act. 2019 Jan 24;:1-13 Authors: Rothenbacher D, Dallmeier D, Denkinger MD, Boehm BO, Koenig W, Klenk J, ActiFE Study Group Abstract Besides its known function as a transport protein for testosterone and other steroid hormones, sex hormone-binding globulin (SHBG), is a biomarker associated with many adverse health effects. The aim of this study was to investigate the association of physical activity with SHBG serum levels in older adults. Physical activity and SHBG values for 1,259 older adults (43.4 % female, 56.6 % male) mean age of (75.6 ± 6.5) years were included in the analysis. Average daily walking duration was (104.2± SD 40.4) minutes. A positive dose-response relationship of daily walking duration with quartiles of SHBG was seen after adjustment for age, sex, history of cardiovascular diseases, diabetes, smoking, γ-GT, and CRP (p-for trend = 0.010). However, this relationship disappeared after adjustment for BMI (p-for trend = 0.977). BMI seems to be an important determinant of SHBG and a possible confounding factor in the relationship of physical activity and SHBG. PMID: 30676188 [PubMed - as supplied by publisher]
Source: Journal of Aging and Physical Activity - Category: Geriatrics Tags: J Aging Phys Act Source Type: research