Safety, pharmacokinetics, and pharmacodynamics of lumacaftor and ivacaftor combination therapy in children aged 2–5 years with cystic fibrosis homozygous for F508del-CFTR: an open-label phase 3 study
Publication date: Available online 24 January 2019Source: The Lancet Respiratory MedicineAuthor(s): John J McNamara, Susanna A McColley, Gautham Marigowda, Fang Liu, Simon Tian, Caroline A Owen, David Stiles, Chonghua Li, David Waltz, Linda T Wang, Gregory S SawickiSummaryBackgroundThe efficacy, safety, and tolerability of lumacaftor and ivacaftor are established in patients aged 6 years and older with cystic fibrosis, homozygous for the F508del-CFTR mutation. We assessed the safety, pharmacokinetics, pharmacodynamics, and efficacy of lumacaftor and ivacaftor in children aged 2–5 years.MethodsIn this multicentre, phase 3, open-label, two-part study, we enrolled children aged 2–5 years, weighing at least 8 kg at enrolment, with a confirmed diagnosis of cystic fibrosis who were homozygous for the F508del-CFTR mutation. Children received lumacaftor 100 mg and ivacaftor 125 mg (bodyweight
J. Mater. Chem. A, 2021, Accepted Manuscript DOI: 10.1039/D1TA06779F, PaperMengqi Wu, Xiaohuan Lv, Jianglong Wang, Ruining Wang, Xingqiang Shi, Hu Zhang, Chen-Dong Jin, Yingjin Wei, Ruqian Lian Transition metal oxychlorides (TMOCl) have attracted great attention as promising cathode materials for chloride ion batteries (CIBs). However, current research on TMOCl has been mainly focused on FeOCl and VOCl.... The content of this RSS Feed (c) The Royal Society of Chemistry
This study demonstrates a heterogeneity in defining CMBE among Canadian key opinion leaders. Future work should explore the fidelity of implementation of CBME.
Justin Trudeau says he needs a strong mandate to lead the nation out of the pandemic.
By Sania FarooquiNEW DELHI, India, Sep 20 2021 (IPS) Last year, as the world grappled to survive the Covid-19 Pandemic, Megan Fernandas an accountant living in Toronto, was trying to face her biggest fear, not the COVID-19 virus, but missing her doctor’s appointment after surviving a rigorous fight against stage 2 breast cancer. Meagan had just gotten back to her normal life when the news of the pandemic hit the world. “I live with my family here in the city and we were all at home, even now we barely go out, so we knew we could ensure not getting infected, but god forbid if I had a health escalation or a reac...
Border restrictions on nonessential travel have been extended again, this time through Oct. 21.
It's voting day in Canada. If you have questions, we have you covered.
SAN CARLOS, Calif., Sept. 20, 2021 -- (Healthcare Sales &Marketing Network) -- Galaxy Medical announced today the initiation of the SPACE-AF study with enrollment of the first two patients at Southlake Regional Health Centre in Newmarket, Canada. In the... Devices, Interventional, Cardiology Galaxy Medical, Pulsed Electric Field, Centauri System, cardiac ablation
India, the world's largest vaccine producer, will resume exports and donations of surplus coronavirus vaccines in October after halting them during a devastating surge in domestic infections in April, the health minister said Monday.
Sternotomy is indicated when a goiter cannot be resected via a cervical incision, such as in the case of a substernal goiter extending beyond the aortic arch. In this article, we report a case of a large substernal goiter that was successfully removed using the cervical approach only. This is a case of a 68-year-old woman, diagnosed with goiter 20 years ago, who complained of a neck mass enlargement with associated cough. Pathological examination revealed no malignancy. Computed tomography (CT) scan showed an 11-cm thyroid mass reaching the level of the aortic arch. Preoperatively, we evaluated the substernal extent of the...
Pfizer Inc. and BioNTech said on Monday their COVID-19 vaccine induced a robust immune response in five- to 11-year-olds, and they plan to ask for authorization to use the vaccine in children in that age range in Canada, the United States, Europe and elsewhere as soon as possible.