Ketogenic diet rescues cognition in ApoE4+ patient with mild Alzheimer's disease: A case study

Publication date: Available online 24 January 2019Source: Diabetes & Metabolic Syndrome: Clinical Research & ReviewsAuthor(s): Sarah J. Morrill, Kelly J. GibasAbstractIt has been established that there is a correlation between Alzheimer's disease and apolipoprotein E, specifically the ApoE4 genetic mutation marker. However, the correlation between Apoe4, insulin resistance and metabolic syndrome (MetS) still remains relatively unstudied. As apolipoprotein E has many important physiological functions, individuals with the ApoE4 mutation allele, also known as the Alzheimer's disease gene, are primarily at a greater risk for physiological consequences, specifically cognitive impairment (Chan et al., 2016). In this case study, a 71-year old female with the ApoE4 gene, a family history of Alzheimer's Disease (AD), and a dual diagnosis of mild AD and metabolic syndrome (MetS) was placed on a 10-week nutrition protocol purposed at raising plasma ketones through a low carbohydrate/high fat ketogenic diet (KD), calorie restriction (fasting) and physical and cognitive exercises. Primary biomarkers for MetS were measured pre/mid-/post intervention. The MoCA (Montreal Cognitive Assessment) was administered pre/post intervention. The results were statistically significant. The HOMA-IR decreased by 75% from 13.9 to 3.48. Triglycerides decreased by 50% from 170 to 85. VLDL decreased by 50% from 34 to 17, and HgA1c decreased by 15% from 5.7% to 4.9%. The baseline MoCA score was 21/30; post t...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research