Free radicals in Alzheimer's disease: Lipid peroxidation biomarkers

Publication date: Available online 24 January 2019Source: Clinica Chimica ActaAuthor(s): Carmen Peña-Bautista, Miguel Baquero, Máximo Vento, Consuelo Cháfer-PericásAbstractAlzheimer's disease (AD), the most common form of dementia, has tremendous social and economic impact worldwide. Research has shown an association between pathologic development of AD and increased free-radical production. As such, the role of peroxidation in brain lipid damage and AD progression has received special attention. Previous studies on lipid peroxidation have improved our understanding of the unique pathophysiologic processes involved in AD. These studies have also served to identify potentially new biomarkers including lipid peroxidation metabolites for diagnosis, prognosis and therapy. Unfortunately, these putative markers have generated controversial results and further research, especially early stage AD, is clearly warranted. The aim of this paper is to review the usefulness of lipid peroxidation biomarkers in AD diagnosis and prognosis as well as monitoring disease development and therapeutic treatment thereof.
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research

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Publication date: Available online 19 March 2019Source: NeuroImage: ClinicalAuthor(s): Ellen Dicks, Lisa Vermunt, Wiesje M. van der Flier, Pieter Jelle Visser, Frederik Barkhof, Philip Scheltens, Betty M. Tijms, for the Alzheimer's Disease Neuroimaging InitiativeAbstractBackgroundGrey matter (GM) atrophy in Alzheimer's disease (AD) is most commonly modeled as a function of time. However, this approach does not take into account inter-individual differences in initial disease severity or changes due to aging. Here, we modeled GM atrophy within individuals across the AD clinical spectrum as a function of time, aging and MMSE...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
The Academy for Health and Lifespan Research was recently announced, an initiative analogous to that of the long-running Longevity Dividend group, but hopefully more energetic and more focused on at least some rejuvenation biotechnologies such as senolytic therapies. The principals include many of the researchers now involved in startup biotech companies working on ways to intervene in the mechanisms of aging, and the goal is to generate greater support for development of means to slow or reverse aging and age-related disease. David Sinclair is associated with Life Biosciences and its collection of portfolio companies, and...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
CONCLUSION: The hypothesis that patients are likely to be overweight or obese before the development of AD and that this may be associated with an increased risk of dementia is sugg ested.RESUMO OBJETIVO: Foram estudados os usu ários do programa de distribuição de medicamentos especializados da rede pública de saúde de Guarapuava, Paraná, Brasil. MÉTODOS: Uma coorte prospectiva, em que os idosos foram examinados em dois momentos, com um intervalo de três anos, com 30 pacientes na fase I e 16 na fase II. A metodolo gia foi composta por visitas domiciliares, avalia&ccedi...
Source: Revista da Associacao Medica Brasileira - Category: General Medicine Source Type: research
DiscussionComputerized cognitive training significantly improved global cognitive function, which was supported by the improved brain plasticity. Incorporation of biomarkers should be implemented in cognitive training trials.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
As Alzheimer ’s disease and dementia affect a growing number of Americans, efforts to keep brain decline at bay have become big business. But in a piece published in the Journal of the American Medical Association, neurologists at the University of California, San Francisco’s Memory and Aging Center, cautio n consumers that brain health supplements have no proven benefit, calling them “pseudomedicine.” In the strongly worded opinion piece, the researchers stress that there are no known supplements…
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
One day, a quick eye test may be able to pick up important information about brain health. Specifically, it may be able to identify signs of dementia.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Alzheimer's / Dementia Source Type: news
Hyun-Sik Yang, MD, of the Department of Neurology, was selected for the 2019 Robert W. Katzman, MD Clinical Research Training Scholarship in Alzheimer ’s and Dementia Research to support his project, “Immunogenetic Alzheimer’s Disease Risk and the Pro
Source: BWH News - Category: Hospital Management Source Type: news
ConclusionsThis comprehensive catalog of utilities showcases the spectrum of diseases and conditions for which caregiver and family members ’ spillover effects have been measured, and the variation in measurement methods used. In general, utilities indicated a loss in quality of life associated with being a caregiver or family member of an ill relative. Most studies reported caregiver/family member utility without any comparator, limi ting the ability to infer spillover effects. Nevertheless, these values provide a starting point for considering spillover effects in the context of CEA, opening the door for more comprehensive analyses.
Source: PharmacoEconomics - Category: Health Management Source Type: research
Discussions with Elders about HousingAging Parents: Where Do They Want to Live Their Last Years? 
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
Authors: Lougiaki P, Tsolaki M, Pantazaki A Abstract Neurovascular dysfunction is a central process in the pathogenesis of the stroke and most neurodegenerative diseases, including Alzheimer's disease. The multi-cell neurovascular unit (NVU) combines the components of the neural, vascular and extracellular matrix (ECM) into an important interface whose proper function is critical to maintaining brain health. Tissue engineering now offers new tools and information to promote understanding of NVU's operation. A promising area for the development of NVU models is their bio-production through 3D bio-printing to produce...
Source: Hellenic Journal of Nuclear Medicine - Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research
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