Mitochondrial stress triggers a pro-survival response through epigenetic modifications of nuclear DNA.

In conclusion, mitochondrial dysfunction leads to a "pro-survival" adaptive state that seems to be triggered by the differential methylation of nuclear genes.
PMID: 30673822 [PubMed - as supplied by publisher]

Source: Cellular and Molecular Life Sciences : CMLS - January 23, 2019 Category: Cytology Authors: Mayorga L, Salassa BN, Marzese DM, Loos MA, Eiroa HD, Lubieniecki F, García Samartino C, Romano PS, Roqué M Tags: Cell Mol Life Sci Source Type: research