Distinct molecular programs regulate synapse specificity in cortical inhibitory circuits

In this study, we investigated transcriptional dynamics in different classes of interneurons during the formation of cortical inhibitory circuits in mouse. We found that whether interneurons form synapses on the dendrites, soma, or axon initial segment of pyramidal cells is determined by synaptic molecules that are expressed in a subtype-specific manner. Thus, cell-specific molecular programs that unfold during early postnatal development underlie the connectivity patterns of cortical interneurons.

Source: ScienceNOW - January 24, 2019 Category: Science Authors: Favuzzi, E., Deogracias, R., Marques-Smith, A., Maeso, P., Jezequel, J., Exposito-Alonso, D., Balia, M., Kroon, T., Hinojosa, A. J., F. Maraver, E., Rico, B. Tags: Neuroscience reports Source Type: news