Silencing the PIK3CA Gene Enhances the Sensitivity of Childhood Leukemia Cells to Chemotherapy Drugs by Suppressing the Phosphorylation of Akt.

CONCLUSION: PIK3CA silencing inhibited Nalm-6 cell proliferation and invasion, and promoted their apoptosis and sensitivity to chemotherapeutic drugs, potentially through regulation of the PI3K/AKT signaling pathway.
PMID: 30666840 [PubMed - in process]

Source: Yonsei Medical Journal - January 24, 2019 Category: Universities & Medical Training Authors: Liang X, Xin X, Qi D, Fu C, Ding M Tags: Yonsei Med J Source Type: research