Incremental cost ‐effectiveness of evidence‐based non‐surgical weight loss strategies

Recent medical advancements have led to new modes of treatment for non ‐surgical weight loss, including several new medications. Our aim was to conduct an incremental cost‐effectiveness analysis for all commercially available, evidence‐based non‐surgical weight loss interventions for people with excess weight. We identified interventions through a systematic re view of randomized controlled trials that reported weight loss 12 months from baseline. We then meta‐analysed the results, sourced costs and performed an incremental cost‐effectiveness analysis from the payer perspective. Cost‐effectiveness was presented in terms of cost per kilogram lost an d quality‐adjusted life years (QALY) gained. We further performed sensitivity analyses on costs and duration of benefits, and a probabilistic sensitivity analysis. Ten interventions were identified for inclusion: six pharmaceutical products (Alli, Xenical, Qsymia, Contrave, Belviq and Saxenda), tw o lifestyle modification programmes (Weight Watchers Meetings and Online), one food replacement and lifestyle programme (Jenny Craig) and one intragastric balloon system (Orbera). At an incremental cost‐effectiveness ratio of $30 071 per additional QALY gained, only Weight Watchers Meetings was cost‐effective. Sensitivity analyses revealed that for the medications to become incrementally cost‐effective, costs would have to decrease by as much as 91%. Results are highly dependent on duration that benefits are main...
Source: Clinical Obesity - Category: Eating Disorders & Weight Management Authors: Tags: ORIGINAL RESEARCH ARTICLE Source Type: research