Measuring Alloreactive B Cell Responses in Transplant Recipients

AbstractPurpose of ReviewDespite advanced immunosuppression, donor-specific antibodies (DSA) remain the leading cause of acute and chronic transplant tissue injury. Comprehensive evaluation of anti-donor humoral immune responses is critical for successful prevention, diagnosis, and treatment of antibody-mediated rejection. This review summarizes the evolution of techniques used for this purpose in experimental and clinical transplantation.Recent FindingsFor decades, measuring DSA serum levels was the only way to assess recipient humoral immunity. Recently, the interest shifted from quantifying circulating DSA to the analyses of various B cell subsets and most importantly, of donor antigen-specific B cells. State-of-the-art approaches have been developed by studies of model antigens, infectious agents, and autoimmunity. These methods are now being adopted by the transplantation field.SummaryThe complexity of humoral immunity caused by organ transplantation necessitates complementary approaches assessing both DSA and various B cell subsets to successfully target antibody-mediated rejection.
Source: Current Transplantation Reports - Category: Transplant Surgery Source Type: research

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Hi everyone, As we know Heart Failure and Transplant fellowship is going for match this year. I just submitted my application, lets use this thread to connect people who are applying to it. Please share our interview invites and also I saw that some of the big programs like Mayo clinic, Univ of Michigan are not taking part in the ERAS. Does anyone know if they took already decided there candidate or do we need to apply to them separately? Does any one know any other programs who have... Advance Heart Failure and Transplant fellowship 2019-2020
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Cardiology Source Type: forums
Authors: Dutta SK, Verma S, Jain V, Surapaneni BK, Vinayek R, Phillips L, Nair PP Abstract The role of the microbiome in health and human disease has emerged at the forefront of medicine in the 21st century. Over the last 2 decades evidence has emerged to suggest that inflammation-derived oxidative damage and cytokine induced toxicity may play a significant role in the neuronal damage associated with Parkinson's disease (PD). Presence of pro-inflammatory cytokines and T cell infiltration has been observed in the brain parenchyma of patients with PD. Furthermore, evidence for inflammatory changes has been reported i...
Source: Journal of Neurogastroenterology and Motility - Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research
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Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research
Dr Alok Patel speaks with Dr Jessica Allegretti on what she learned from applying fecal microbiota transplantation as a treatment for obesity in otherwise healthy patients.Medscape Gastroenterology
Source: Medscape Gastroenterology Headlines - Category: Gastroenterology Tags: Gastroenterology Commentary Source Type: news
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Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Condition:   Liver Transplantation Intervention:   Drug: Omega 3 fatty acid Sponsor:   Institute of Liver and Biliary Sciences, India Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   New Onset Diabetes After Transplant;   Diabetes Mellitus Intervention:   Other: group education Sponsor:   Dasman Diabetes Institute Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Temple University Hospital and Bethlehem-based St. Luke ’s University Health Network said Tuesday they have entered into an expanded affiliation that now includes lung transplants and advance lung disease care. Financial terms of the deal were not announced. Under the partnership, patients living in the Lehigh Valley will get “streamlined” access — close to home — to Temple’s experienced lung transplant team and pulmonology specialists. The alliance expands on the clinical affiliation…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
Although modifications of gut microbiota with antibiotics (Abx) influence mouse skin and cardiac allografts, its role in orthotopic liver transplantation (OLT) remains unknown. We aimed to determine whether and how recipient Abx pretreatment may affect hepatic ischemia-reperfusion injury (IRI) and OLT outcomes. Mice (C57BL/6) with or without Abx treatment (10 days) were transplanted with allogeneic (BALB/c) cold-stored (18 hours) livers, followed by liver and blood sampling (6 hours). We divided 264 human OLT recipients on the basis of duration of pre-OLT Abx treatment into control (Abx-free/Abx
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Organ transplantation is now a preferred treatment for end-stage organ failure. Among the challenges for ensuring excellent clinical outcomes for transplant recipients is good initial allograft function at the time of organ implantation. This is determined in part by the functional status of the donor and donor organ, functional status of the recipient, and conduct of the operative procedure. Despite optimization of these variables, organ transplantation is still often plagued by substantial initial dysfunction, variably referred to as slow or delayed graft function, or in the most extreme cases, primary graft nonfunction ...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
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