Pulmonologists more open to CT lung cancer screening

Pulmonologists and primary care physicians have contrasting opinions regarding...Read more on AuntMinnie.comRelated Reading: New decision aids may revamp CT lung cancer screening Are patients adequately informed about CT lung screening? Patient outreach may boost uptake for CT lung screening 5 ways to optimize CT lung cancer screening Family doctors unclear on CT lung cancer screening
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news

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This study demonstrates the inhibition activity of kaempferol and myricetin and the structure-function relationship of these two flavonoid and previously isolated flavonoids from Vernonia cinerea and Pluchea indica against both enzymes. 3. Kaempferol could inhibit CYP2A6 with Kic value of 1.77 ± 0.47 µM while inhibit CYP2A13 with Kic value of 0.12 ± 0.01 µM. Myricetin could inhibit CYP2A6 with Kic value of 4.06 ± 0.52 µM while inhibit CYP2A13 with Kic value of 1.88 ± 0.03 µM. 4. Molecular docking indicated that CYP2A...
Source: Xenobiotica - Category: Research Authors: Tags: Xenobiotica Source Type: research
CONCLUSIONS: While clinicians feel that LDCT LCS may benefit some HNC survivors, there are barriers both to implementing LCS SDM for these patients in primary care as currently recommended and to integrating it into cancer clinics. Challenges for SDM across settings include a lack of decision aids tailored to patients with cancer histories. Given recommendations to broaden LCS eligibility criteria, more research may be required before refinement of current guidelines. PMID: 31409114 [PubMed - as supplied by publisher]
Source: The Annals of Otology, Rhinology, and Laryngology - Category: ENT & OMF Authors: Tags: Ann Otol Rhinol Laryngol Source Type: research
Conclusion: Treatment with PD-1 inhibitors seems to have an efficacy signal and be well tolerated in PLWHIV, including impact on CD4+ lymphocyte count and HIV load, that should be monitored during treatment course (regarding real-life experience).
Source: AIDS - Category: Infectious Diseases Tags: FAST TRACK Source Type: research
In Reply We thank De Allie and colleagues for their comments on our article. We agree that many primary care physicians (PCPs) lack skills in shared decision making (SDM), particularly SDM using decision aids. This lack should be ameliorated by incorporation of education on decision aids into undergraduate, postgraduate, and continuing medical education. Formal SDM with decision aids is one method to promote patient-centered medicine, as are good listening skills and sufficient time budgeted for clinical encounters to create space for patients to express their values and preferences.
Source: JAMA Internal Medicine - Category: Internal Medicine Source Type: research
ConclusionsThe use of intraoperative electromagnetic transthoracic nodule localization prior to thoracoscopic resection of small and/or difficult to palpate lung nodules is safe and effective, potentially eliminating the need for direct nodule palpation. Use of this technique aids in minimally invasive localization and resection of small, deep and/or ground-glass lung nodules.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Publication date: Available online 20 June 2019Source: Biochimica et Biophysica Acta (BBA) - BioenergeticsAuthor(s): Harry G. Sherman, Carolyn Jovanovic, Alaa Abuawad, Dong-Hyun Kim, Hilary Collins, James E. Dixon, Robert Cavanagh, Robert Markus, Snow Stolnik, Frankie J. RawsonAbstractTrans-plasma membrane electron transfer (tMPET) is a process by which reducing equivalents, either electrons or reductants like ascorbic acid, are exported to the extracellular environment by the cell. TPMET is involved in a number of physiological process and has been hypothesised to play a role in the redox regulation of cancer metabolism. ...
Source: Biochimica et Biophysica Acta (BBA) Bioenergetics - Category: Biochemistry Source Type: research
CONCLUSIONS: The use of intraoperative electromagnetic transthoracic nodule localization prior to thoracoscopic resection of small and/or difficult to palpate lung nodules is safe and effective, potentially eliminating the need for direct nodule palpation. Use of this technique aids in minimally invasive localization and resection of small, deep and/or ground-glass lung nodules. PMID: 31233723 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Ann Thorac Surg Source Type: research
AbstractBackground.Patients with a history of autoimmune diseases (AIDs) have not usually been included in clinical trials with immune checkpoint inhibitors.Materials and Methods.Consecutive patients with advanced cancer, treated with anti‐programmed death‐1 (PD‐1) agents, were evaluated according to the presence of pre‐existing AIDs. The incidence of immune‐related adverse events (irAEs) and clinical outcomes were compared among subgroups.Results.A total of 751 patients were enrolled; median age was 69 years. Primary tumors were as follows: non‐small cell lung cancer, 492 (65.5%); melanoma, 159 (21.2%);...
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Precision Medicine Clinic: Molecular Tumor Board Immuno ‐ Oncology Source Type: research
Go online to PeerView.com/UXH860 to view the activity, download slides and practice aids, and complete the post-test to earn credit. In this activity, experts in oncology discuss various treatment options for small cell lung cancer (SCLC), including the rationale for using new therapies, key clinical trial data, and methods for integrating novel therapies into routine practice or through clinical trial participation. Upon completion of this activity, participants will be able to: Describe the mechanisms of action and rationale for use of novel therapies for SCLC, including immune checkpoint inhibitors, PARP inhibitors, tra...
Source: Peerview CME/CE Video Podcast - Internal Medicine International - Category: Internal Medicine Authors: Tags: Science, Medicine Source Type: video
Conclusions: In a national antiretroviral-era cohort of lung cancer patients undergoing surgical lung resection, short-term outcomes after surgery did not differ significantly by HIV status. Concerns regarding short-term surgical complications should have limited influence on treatment decisions for PWH with lung cancer.
Source: AIDS - Category: Infectious Diseases Tags: EPIDEMIOLOGY AND SOCIAL Source Type: research
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