Birth Control Pills and Thrombotic Risks: Differences of Contraception Methods with and without Estrogen.

Birth Control Pills and Thrombotic Risks: Differences of Contraception Methods with and without Estrogen. Hamostaseologie. 2019 Jan 22;: Authors: Rott H Abstract In Germany one-third of the women in fertile age use combined oral contraceptives (COCs), which consist mostly of ethinylestradiol (EE) and a synthetic progestin. Older COCs with norethisterone or levonorgestrel have a lower risk for venous thromboembolism (VTE) than newer COCs with desogestrel, drospirenone, or gestodene. This is also true for nonoral combined hormonal contraceptives. The risk of newer COCs containing estradiol instead of EE is not clear due to missing data. Progestin-only hormonal contraception is not associated with a significant increase of the risk for VTE with the exception of depot medroxyprogesterone acetate. Emergency contraceptions, which do not contain EE, but only levonorgestrel or ulipristal acetate, do not result in a higher risk for VTE. Oral desogestrel- or levonorgestrel-only contraceptives, intrauterine device, and etonogestrel implants are the contraception of choice in women with a history of VTE and/or suffering from thrombophilia. These safe contraceptives should be offered to women with high risk of VTE due to the much higher VTE risk in pregnancy and postpartum. The screening for thrombophilia is not indicated in every woman with the wish for contraception. This should be restricted to certain cases, for example to women with a positive history for VTE or...
Source: Hamostaseologie - Category: Hematology Authors: Tags: Hamostaseologie Source Type: research

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Publication date: Available online 1 June 2020Source: Urology Case ReportsAuthor(s): Ibrahim Boukhannous, Tarik Mhanna, Amine EL. Houmaidi, Mohammed Aynaou, Mehdi Chennoufi, Ali Barki
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
Abstract Cerebral venous thrombosis (CVT) is an uncommon cause of stroke that mainly affects young adults with known risk factors of prothrombotic conditions, pregnancy, infection, malignancy, and drugs. Dutasteride is a 5α-reductase inhibitor that is used for benign prostate hypertrophy and androgenetic alopecia. To date, CVT caused by dutasteride use has not been reported. A 25-year-old male presented with headache and diplopia. He had taken 0.5 mg of dutasteride every other day for 9 months to treat alopecia. A headache developed 7 months after he started taking medication, and horizontal diplopia occurre...
Source: Yonsei Medical Journal - Category: Universities & Medical Training Authors: Tags: Yonsei Med J Source Type: research
Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by persistently positive antiphospholipid antibodies (aPLs) and clinical manifestations of thrombosis or obstetrical complications including pregnancy loss or pre-term delivery
Source: Thrombosis Research - Category: Hematology Authors: Tags: Letter to the Editors-in-Chief Source Type: research
AbstractPulmonary embolism (PE) is the third most frequent acute cardiovascular syndrome. Annual PE incidence and PE-related mortality rates rise exponentially with age, and consequently, the disease burden imposed by PE on the society continues to rise as the population ages worldwide. Recently published landmark trials provided the basis for new or changed recommendations included in the 2019 update of the European Society of Cardiology Guidelines (developed in cooperation with the European Respiratory Society). Refinements in diagnostic algorithms were proposed and validated, increasing the specificity of pre-test clini...
Source: Internal and Emergency Medicine - Category: Emergency Medicine Source Type: research
amo JA, Ruiz-Martinez S PMID: 32449242 [PubMed - as supplied by publisher]
Source: The Ultrasound Review of Obstetrics and Gynecology - Category: Radiology Authors: Tags: Ultrasound Obstet Gynecol Source Type: research
Conclusion: There are some gaps in the research, and clinical studies with appropriate methodology are needed to support decisions made regarding the risk of thromboembolism in the perigestational period. Thus, the attention of the professionals involved in the care of pregnant and postpartum women is crucial, as it is a condition associated with high morbidity and mortality.Resumo Objetivo Identificar as estrat égias e recomendações atuais para profilaxia de tromboembolismo venoso associado ao ciclo gravídico-puerperal, condição de alta morbimortalidade entre mulheres. Méto...
Source: Revista Brasileira de Ginecologia e Obstetricia - Category: OBGYN Source Type: research
Leiomyosarcomas are an uncommon malignant subset of tumors accounting for approximately 20% of soft tissue sarcomas. Primary vascular leiomyosarcomas (PVL) are a rare subset of leiomyosarcomas that may originate in the arterial or venous circulation, but most commonly affect the inferior vena cava (IVC).1 PVLs more commonly affect women to men in a 2:1 ratio and most frequently occur in the 4th to 6th decades of life. Few reports have described this infrequent pathologic state in the setting of advanced pregnancy.
Source: Annals of Vascular Surgery - Category: Surgery Authors: Tags: Case Report Source Type: research
AbstractBackgroundSpecific anti-phospholipids antibodies (aPLs) are used as classification criteria of the antiphospholipid syndrome (APS). These aPLs, although essential for diagnosis, do not predict disease phenotypes, which may require specific therapies. Non-criteria aPLs are rarely evaluated and their role is yet to be defined. In the current study, we aimed to examine the association between criteria and non-criteria aPLs and APS phenotypes.MethodsSerum samples from 188 subjects, 130 APS patients and 58 controls were analyzed for the presence of 20 aPLs (IgG and IgM isotypes to cardiolipin (CL), beta2-glycoprotein1 (...
Source: Autoimmunity Highlights - Category: Allergy & Immunology Source Type: research
Abstract Antiphospholipid syndrome (APS) is one of the more common acquired causes of hypercoagulability. Its major presentations are thrombotic (arterial, venous or microvascular) and pregnancy morbidity (miscarriages, late intrauterine fetal demise, and severe pre-eclampsia). Classification criteria include three different antiphospholipid antibodies: lupus anticoagulant; anticardiolipin; and anti-beta 2 glycoprotein I. Management includes both preventive strategies (low dose aspirin, hydroxychloroquine) and long-term anticoagulation after thrombosis. PMID: 32413497 [PubMed - as supplied by publisher]
Source: Translational Research : the journal of laboratory and clinical medicine - Category: Laboratory Medicine Authors: Tags: Transl Res Source Type: research
Antiphospholipid syndrome (APS) is one of the more common acquired causes of hypercoagulability. Its major presentations are thrombotic (arterial, venous or microvascular) and pregnancy morbidity (miscarriages, late intrauterine fetal demise, and severe pre-eclampsia). Classification criteria include three different antiphospholipid antibodies: lupus anticoagulant; anticardiolipin; and anti-beta 2 glycoprotein I. Management includes both preventive strategies (low dose aspirin, hydroxychloroquine) and long-term anticoagulation after thrombosis.
Source: Translational Research - Category: Research Authors: Tags: Review Article Source Type: research
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