Targetable Gene Fusions Identified in Radioactive Iodine-Refractory Advanced Thyroid Carcinoma.

CONCLUSION: Targetable gene fusions were found in 12% of RAI-R thyroid carcinoma without DNA variants, and can be effectively identified in formalin-fixed tissue. These gene fusionsmight provide a preclinical rationale to include specific kinase inhibitors in the treatment regimen for these patients. The latter intends to restore iodine transport and/or take advantage of the direct effect on tumor cell vitality once progressive disease is seen.
PMID: 30668525 [PubMed - as supplied by publisher]

Source: European Journal of Endocrinology - January 1, 2019 Category: Endocrinology Authors: van der Tuin K, Ventayol M, Corver W, Khalifa M, Ruano D, Corssmit EP, Hes FJ, Links TP, Smit J, Plantinga TS, Kapiteijn E, Van Wezel T, Morreau H Tags: Eur J Endocrinol Source Type: research