Insulin Price More Than Doubles in U.S.
Title: Insulin Price More Than Doubles in U.S.Category: Health NewsCreated: 1/23/2019 12:00:00 AMLast Editorial Review: 1/23/2019 12:00:00 AM
We reported that, while autophagy was necessary for β cell survival, the highly conserved Sel1L-Hrd1 ERAD protein complex was required for the maintenance of β cell maturation and identity. Using single-cell RNA-Seq, we demonstrated that Sel1L deficiency was not associated with β cell loss, but rather loss of β cell identity. Sel1L-Hrd1 ERAD controlled β cell identity via TGF-β signaling, in part by mediating the degradation of TGF-β receptor 1. Inhibition of TGF-β signaling in Sel1L-deficient β cells augmented the expression of β cell maturation markers and increased the t...
Authors: Tomiyama H, Shiina K Abstract The brachial-ankle pulse wave velocity (brachial-ankle PWV), which is measured simply by wrapping pressure cuffs around the four extremities, is a simple marker to assess the stiffness of the medium- to large- sized arteries. The accuracy and reproducibility of its measurement have been confirmed to be acceptable. Risk factors for cardiovascular disease, especially advanced age and high blood pressure, are reported to be associated with an increase of the arterial stiffness. Furthermore, arterial stiffness might be involved in a vicious cycle with the development/progression o...
Authors: Kobayashi M, Satoh H, Matsuo T, Kusunoki Y, Tokushima M, Watada H, Namba M, Kitamura T Abstract Glucagon dysfunction as well as insulin dysfunction is associated with the pathogenesis of type 2 diabetes (T2DM). However, it is still unclear whether the measurement of plasma glucagon levels is useful in understanding the pathophysiology of T2DM. We recently reported that sandwich ELISA provides more accurate plasma glucagon values than conventional RIA in healthy subjects. Here we used sandwich ELISA as well as RIA to assess plasma glucagon levels, comparing them in T2DM patients and healthy subjects during ...
CONCLUSION: Healing without major amputation was achieved in 84% of surviving patients ≥75 years, despite extensive comorbidity and dependency. PMID: 32448021 [PubMed - as supplied by publisher]
Publication date: Available online 26 May 2020Source: Diabetes &Metabolic Syndrome: Clinical Research &ReviewsAuthor(s): Karthikeyan Iyengar, Gaurav K. Upadhyaya, Raju Vaishya, Vijay Jain
Publication date: Available online 26 May 2020Source: Canadian Journal of DiabetesAuthor(s): Krista Banasiak, Devin Cleary, Virtue Bajurny, Pina Barbieri, Seema Nagpal, Michelle Sorensen, Nadia Tabiou, Holly Witteman, Peter Senior
Publication date: Available online 25 May 2020Source: Pharmacological ResearchAuthor(s): Hui-Yao Li, Yue Yuan, Yu-Hong Fu, Ying Wang, Xin-Yuan Gao
Publication date: Available online 25 May 2020Source: Pharmacological ResearchAuthor(s): Chunyan Zhu, Tingting Cai, Ying Jin, Jiayun Chen, Guoqiang Liu, Niusheng Xu, Rong Shen, Yuhong Chen, Luying Han, Suping Wang, Caisheng Wu, Mingshe Zhu
CONCLUSIONS: Most studies found GDM screening to be cost-effective, though uncertainties remain due to many factors. The quality assessment identified weaknesses in the economic evaluations in terms of integrating existing data, measuring costs and consequences, analyzing perspectives, and adjusting for uncertainties. PMID: 32448822 [PubMed - as supplied by publisher]
TYPE 2 diabetes can cause long term complications if blood sugar levels are not brought under control. Fortunately, making healthy lifestyle choices can ward off the threat of high blood sugar levels and taking a particular herbal extract has been shown to be effective.