Current Status of Maintenance Systemic Therapies in Metastatic Colorectal Cancer: 2018 Update

This article is an update of the 2017 review by Quidde et al. and evaluates the most recent data on maintenance strategies in MCRC.Recent FindingsInduction followed by maintenance and if feasible re-induction treatment does not seem to be inferior to continuous full-dose treatment for patients with MCRC responding to first-line combination regimen but without options for secondary resection or local ablation. Active maintenance seems to be superior to complete stop after at least 3  months of induction treatment in terms of progression-free survival and may add some benefit in terms of OS. The addition of PD-L1 inhibition to maintenance was not effective. The choice of the respective maintenance strategy may be personalised taking into account disease and patient characterist ic, choice of induction treatment and response, treatment tolerability and quality of life.SummaryPatients with MCRC and no options of secondary resection or local ablation should be considered for maintenance treatment.
Source: Current Colorectal Cancer Reports - Category: Cancer & Oncology Source Type: research