Progesterone to number of mature oocyte index is a better predictor of live birth than blood progesterone level in GnRH antagonist protocols
Publication date: Available online 23 January 2019Source: Reproductive BioMedicine OnlineAuthor(s): Cynthia Simon, Lise Branet, Jessika Moreau, Nicolas Gatimel, Clementine Cohade, Florence Lesourd, Jean Parinaud, Roger LeandriABSTRACTResearch questionWhat is the part of blood progesterone (P) level and progesterone to mature oocytes index (PMOI) in in-vitro fertilization (IVF) outcomes.DesignClinical data from 960 couples undergoing their first fresh embryo transfer after an ICSI (intracytoplasmic sperm injection) attempt performed between September 2012 and July 2017 were analysed. All patients underwent ovarian stimulation combining recombinant FSH and GnRH antagonist. P was measured on the day on which ovulation was triggered. P and PMOI were divided into groups based on 25th, 50th and 75th percentiles and live birth and implantation rates were compared between the groups.ResultsThere was a negative association between PMOI levels and live birth and implantation rates. When adjusting for age, ovarian stimulation index (OSI) and number of embryos transferred, the PMOI remained negatively correlated to the live birth rate while total blood P was no longer evident. Moreover, high PMOI (75th percentile) was associated with low ICSI outcome even when P was not elevated (
ConclusionsInfertile women with UI undergoing assisted reproduction demonstrate different demographic and clinical characteristics compared to those of other causes of infertility, albeit live birth rates are similar.
ConclusionsThe novel mutation of c. 156 G>T inCD40LG gene probably leads to XHIGM by nonsense-meditated mRNA decay (NMD), and complex PGT of preimplantation genetic testing for monogenic disease (PGT-M), aneuploidy (PGT-A), structural rearrangement (PGT-SR), and HLA-matching (PGT-HLA) can be performed in pedigree with both X-linked hyper IgM syndrome and Robertsonian translocation.
Conditions: Infertility; Infertility, Female; IVF; hCG Interventions: Drug: hCG; Diagnostic Test: Ultrasound; Other: Blood test Sponsor: IVI Middle East Fertility Clinic Not yet recruiting
Abstract As the final and critical step in in vitro fertilization (IVF), embryo transfer has always received much attention and deserves continuous optimization. In the present study, to explore the role of autocrine factors in embryo self-spent culture media, we prospectively compared embryo transfer with self-spent culture medium and fresh medium on clinical pregnancy outcomes. A total of 318 fresh IVF/intracytoplasmic sperm injection (ICSI) cycles were randomly allocated into two subgroups based on their transfer media (using a self-spent culture medium or new pre-equilibrated culture media), and the clinical o...
Abstract Objective: To investigate the feasibility and clinical outcome of the all-blastocyst-culture and single blastocyst transfer strategy in women aged ≥35 years. Methods: A retrospective analysis of patients aged ≥35 years undergoing IVF/ICSI was performed from January 2017 to April 2019 in the reproductive center of the Second Affiliated Hospital of Wenzhou Medical University. A total of 155 cases treated with ovarian hyperstimulation by prolonged protocol and implemented single (84 cases) or double (71 cases) blastocyst transfer were collected. Then, patients were further divided into
Abstract We retrospectively analyzed clinical data from 45,912 in vitro fertilization/intracytoplasmic sperm injection cycles in our reproductive medical center. We compared the clinical outcomes of three different ovarian hyperstimulation protocols in poor ovarian responders (classified by the POSEIDON criteria) to determine the most effective protocol for each POSEIDON group. In POSEIDON groups 1 and 3, the early-follicular-phase long-acting GnRH-agonist long (EFLL) protocol was associated with higher pregnancy rates per transfer and higher live birth rates than the mid-luteal-phase short-acting GnRH-agonist lon...
Conclusion: Our results indicated that GnRH agonist pre-treatment before starting the long GnRH agonist protocol does not improve the live birth rate in fresh embryo transfer cycles or CLBR in infertile women with adenomyosis after IVF/ICSI treatment when compared to that in non-pre-treated patients. A subsequent prospective randomized controlled study is needed to confirm these results.
ConclusionAlthough the average genome ‐wide level of sperm DNA methylation was similar in both sample groups, a distinctive number of methylation changes were observed in DMR and DMP levels. A larger number of samples should be analyzed and additional sperm preparation methods should be tested to confirm our findings.
ConclusionAfro-Caribbean women receiving infertility care in the Caribbean may have better ART outcomes compared to African-American women in the United States (US).
The objective of this study was to examine the effectiveness and safety of ovarian stimulation (OS) with follitropin alfa (Ovaleap®) for routine IVF or intracytoplasmic sperm injection treatment in gonadotropin-releasing hormone (GnRH) antagonist cycles in real-world ART clinical practice. METHODS: This non-interventional, multicenter, prospective study was initiated in 34 specialized reproductive medicine centers in Germany. Eligible women were 18-40 years old with a body mass index