Topical Ketoconazole: A Systematic Review of Current Dermatological Applications and Future Developments.

This article aims to review the literature on topical KTZ's efficacy and adverse effects, as well as provide an overview on current insights regarding its mechanism of action and upcoming developments. METHODS: A PubMed search was done to include randomized-controlled trials focusing on the use of topical KTZ on human subjects. RESULTS: Forty studies with 4566 patients were included in this review. Topical KTZ is clinically effective for the treatment of Malassezia-related conditions such as seborrheic dermatitis and pityriasis versicolor with a reported efficacy of 63-90% and 71-89%, respectively. DISCUSSION: Topical KTZ demonstrates high clinical efficacy for Malassezia-related conditions. More efficacious alternatives are now available for Tinea and Candida. Although topical KTZ is safe, clinicians should be aware that allergic contact dermatitis may occur. Further studies should be completed to investigate the use of topical KTZ for hair loss and inflammatory dermatoses. PMID: 30668185 [PubMed - as supplied by publisher]
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research