Lung Transplant Valid in SSc

(MedPage Today) -- Patients with systemic sclerosis shouldn't be denied lung transplants.
Source: MedPage Today Meeting Coverage - Category: Journals (General) Source Type: news

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Purpose of review To provide an overview of recently published work on autologous hematopoietic stem-cell transplantation (HSCT) in patients with systemic sclerosis (SSc). Recent findings Superiority of HSCT vs. intravenous cyclophosphamide pulses was demonstrated in the randomized controlled American Scleroderma: Cyclophosphamide or Transplantation (SCOT) Trial (n = 75), supporting the results from earlier studies. In the SCOT Trial, total body irradiation was used instead of the nonmyeloablative regimens used in other trials, and considered well tolerated during a follow-up time of 4.5 years. Three small uncontr...
Source: Current Opinion in Rheumatology - Category: Rheumatology Tags: RAYNAUD PHENOMENON, SCLERODERMA, OVERLAP SYNDROMES AND OTHER FIBROSING SYNDROMES: Edited by John Varga Source Type: research
Purpose of review The purpose of this review is to highlight recent data regarding feasibility and outcomes following lung transplantation for patients with systemic sclerosis related pulmonary disease as well as to emphasize areas of uncertainly in need of further study. We include a description of our centre's approach to lung transplant evaluation and posttransplant management in this complex patient population. Recent findings Historical data have demonstrated that patients with scleroderma have an increased risk of complications following lung transplantation owing to the multisystem nature of disease, particular...
Source: Current Opinion in Rheumatology - Category: Rheumatology Tags: RAYNAUD PHENOMENON, SCLERODERMA, OVERLAP SYNDROMES AND OTHER FIBROSING SYNDROMES: Edited by John Varga Source Type: research
AbstractPurpose of ReviewConnective tissue disease-related interstitial lung disease (CTD-ILD) previously was a relative contraindication to lung transplantation primarily due to extra-pulmonary involvement of the disease. Recent published information focusing on the diagnosis and management of the extra-pulmonary complexities associated with CTD-ILD that challenge the success of lung transplantation indicate similar outcomes when compared to idiopathic causes of interstitial lung disease. Recent literature examining appropriate wait-listing criteria, disease management, and outcomes after lung transplantation are discusse...
Source: Current Respiratory Care Reports - Category: Respiratory Medicine Source Type: research
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Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
CONCLUSION: The diagnostics and treatment of CTD-ILD and PH in patients with an underlying autoimmune disease requires an interdisciplinary approach. The effectiveness of antifibrotic treatment needs to be evaluated in the future. PMID: 30006857 [PubMed - as supplied by publisher]
Source: Zeitschrift fur Rheumatologie - Category: Rheumatology Authors: Tags: Z Rheumatol Source Type: research
Due to its multisystemic nature, scleroderma (SSc) remains a relative contraindication to lung transplantation in many transplantation centers. However, recent studies suggest that post-transplant outcomes in patients with SSc do not differ significantly from those in patients with interstitial lung diesase (ILD). However, the impact of SSc-associated pulmonary arterial hypertension (PAH) on post transplant outcome remains unknown. Objective: to investigate demographics, survival and prognostic factors in a multicentric cohort of well-characterized patients with SSc lung disease undergoing lung or heart-lung transplantation.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
This study intended to clarify the clinical features and prognosis of CTD-PAH and compare between SSc-PAH and other CTD-PAH (non SSc-PAH) in Japanese therapeutic era. .
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
Pulmonary arterial hypertension (PAH) is a severe complication of systemic sclerosis (SSc) that warrants early detection. Although resting echocardiography is recommended for screening, exercise echocardiography (EEcho) may detect an abnormal increase in mean pulmonary arterial pressure (PAPm). In addition, multipoint relationship between PAPm and cardiac output (P/Q), a more physiological approach, can be generated during EEcho. Our objective was to analyze the P/Q relationship in SSc patients compared with matched controls.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
Due to its multisystemic nature, scleroderma is considered a relative contraindication to lung transplantation at many centers. However, recent studies suggest similar post-transplant outcomes in patients with scleroderma compared to those with other causes of interstitial lung disease (ILD). Furthermore, it remains unknown whether scleroderma-associated pulmonary arterial hypertension (PAH) influences post-transplant outcomes. Our objective in this study was to assess the indications, survival, and prognostic factors of lung or heart –lung transplantation for scleroderma lung disease.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Original Clinical Science Source Type: research
Due to its multisystemic nature, scleroderma is considered a relative contra-indication to lung transplantation in many centers. However, recent studies suggest similar post-transplant outcomes in patients with scleroderma compared to those with other causes of interstitial lung disease (ILD). Furthermore, whether scleroderma-associated pulmonary arterial hypertension (PAH) influences post-transplant outcomes remains unknown. Our objective here was to assess the indications, survival, and prognostic factors of lung or heart-lung transplantation for scleroderma lung disease.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
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