Urine markers of renal tubular injury in idiopathic membranous nephropathy: A cross sectional study

Publication date: Available online 23 January 2019Source: Clinica Chimica ActaAuthor(s): An Changjuan, Akankwasa Gilbert, Liu Jianhua, Wang Dandan, Cheng Guixue, Zhang Jin, Xiaosong QinAbstractIntroductionIdiopathic membranous nephropathy (IMN) is a primary glomerular disease and a major cause of adult nephrotic syndrome. Presently, little is known about the capabilities of the urine markers to reflect the severity of IMN. We aimed at establishing whether urinary N-acetyl-β-glucosaminidase (NAG), Retinol binding protein (RBP), Kidney injury molecule-1 (KIM-1) and Neutrophil gelatianse-associated lipocalin (NGAL) are related with renal parameters and the histological grades tubular injury.MethodsThe levels of urinary NAG, RBP, KIM-1 and NGAL were determined in 165 biopsy-proven patients and 64 healthy controls. Their levels were then compared between patients and healthy subjects, and between patients with and without nephrotic syndrome. Their linearity with renal parameters and associations with histological grades of renal tubular injury were also assessed.ResultsAll biomarkers were significantly increased in patients (p 
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research

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Conclusions:We provide a simplifed diagnostic algorithm for evaluation of proteinuria in primary care adolescents who appear well and in whom proteinuria is incidentally discovered during a routine examination.Keywords:Adolescents, algorithm, asymptomatic proteinuria, children
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Source: Nephron - Category: Urology & Nephrology Source Type: research
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Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Basic Research Source Type: research
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Source: Journal of Pediatric and Adolescent Gynecology - Category: OBGYN Authors: Source Type: research
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Source: CEN Case Reports - Category: Urology & Nephrology Source Type: research
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Source: CEN Case Reports - Category: Urology & Nephrology Source Type: research
Abstract INTRODUCTION: Idiopathic membranous nephropathy (IMN) is a primary glomerular disease and a major cause of adult nephrotic syndrome. Presently, little is known about the capabilities of the urine markers to reflect the severity of IMN. We aimed at establishing whether urinary N-acetyl-β-glucosaminidase (NAG), Retinol binding protein (RBP), Kidney injury molecule-1 (KIM-1) and Neutrophil gelatianse-associated lipocalin (NGAL) are related with renal parameters and the histological grades tubular injury. METHODS: The levels of urinary NAG, RBP, KIM-1 and NGAL were determined in 165 biopsy-proven pa...
Source: International Journal of Clinical Chemistry - Category: Chemistry Authors: Tags: Clin Chim Acta Source Type: research
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