Predictors and Moderators of Cognitive and Behavioral Therapy Outcomes for OCD: A Patient-Level Mega-Analysis of Eight Sites.

Predictors and Moderators of Cognitive and Behavioral Therapy Outcomes for OCD: A Patient-Level Mega-Analysis of Eight Sites. Behav Ther. 2019 Jan;50(1):165-176 Authors: Steketee G, Siev J, Yovel I, Lit K, Wilhelm S Abstract Cognitive (CT) and behavioral treatments (BT) for OCD are efficacious separately and in combination. Tailoring treatment to patient-level predictors and moderators of outcome has the potential to improve outcomes. The present study combined data from eight treatment clinics to examine the benefits of BT (n = 125), CT (n = 108), and CBT (n = 126), and study predictors across all treatments and moderators of outcome by treatment type. All three methods led to large benefits for OCD and depression symptoms. Residual gain scores for OCD symptoms were marginally smaller for BT compared to treatments containing CT. For depression, significantly more gains were evident for CBT than BT, and CT did not differ from either. Significantly fewer BT participants (36%) achieved clinically significant improvement compared to CT (56%), and this was marginally evident for CBT (48%). For all treatments combined, no predictors were identified in residual gain analyses, but clinically improved patients had lower baseline depression and stronger beliefs about responsibility/threat and importance/control of thoughts. Moderator analyses indicated that higher baseline scores on depression adversely affected outcomes for BT but not CT or CBT, and lower OCD se...
Source: Behavior Therapy - Category: Psychiatry & Psychology Authors: Tags: Behav Ther Source Type: research

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Conclusions: Metrorail systems are unique sources of orthopaedic injuries requiring high rates of critical care and surgical intervention. Patients sustain multiple injuries, many with amputations. With this mechanism, there is a high rate of open fractures and suicide. Trauma centers should emphasize an extensive evaluation of orthopaedic injuries in this patient setting.Level of Evidence: II. PMID: 31413689 [PubMed - in process]
Source: Iowa orthopaedic journal - Category: Orthopaedics Tags: Iowa Orthop J Source Type: research
This study assessed the effect of residual pain, age, sex, diabetes, hypertension, and depression on changes and status at one-year following arthroplasty with respect to shoulder function and overall physical and mental health status. Methods: A retrospective analysis of a prospective cohort of 140 patients tested preoperatively and one-year following shoulder arthroplasty was conducted at our tertiary hospital. Pearson's correlations and multiple regression analysis were performed to test the impact of predictors on shoulder pain and function assessed using the American Shoulder and Elbow Surgery (ASES) questionnaire...
Source: Iowa orthopaedic journal - Category: Orthopaedics Tags: Iowa Orthop J Source Type: research
Publication date: Available online 15 August 2019Source: The Lancet PsychiatryAuthor(s): Maria Semkovska, Lisa Quinlivan, Tara O'Grady, Rebecca Johnson, Aisling Collins, Jessica O'Connor, Hannah Knittle, Elayne Ahern, Taylor GloadSummaryBackgroundSubstantial evidence suggests that cognitive deficits might persist after remission of a major depressive episode. However, results are inconsistent relative to the importance, pattern, severity, and moderating factors of this impairment. We aimed to determine how cognitive function following a major depressive episode compares with normal function, to specify the pattern and seve...
Source: The Lancet Psychiatry - Category: Psychiatry Source Type: research
Publication date: Available online 15 August 2019Source: The Lancet PsychiatryAuthor(s): Richard J Porter, Katie M Douglas
Source: The Lancet Psychiatry - Category: Psychiatry Source Type: research
Publication date: Available online 15 August 2019Source: Neuroscience LettersAuthor(s): J.L. Bollinger, E.S. WohlebAbstractPsychological stress can precipitate depression, and emerging preclinical data suggest a link between stress-induced alterations in microglia function and development of depressive-like behaviors. Microglia are highly dynamic, and play an integral role in maintaining neuronal homeostasis and synaptic plasticity. In this capacity, microglial dysfunction represents a compelling avenue through which stress might disrupt neuronal integrity and induce psychopathology. This review examines preclinical and cl...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
Military personnel who have firearms at home and a history of thoughts of death or self-harm are less likely to store their firearms in a safe manner than those with no such history, astudy inJAMA Network Open has found.Craig J. Bryan, Psy.D., of the National Center for Veterans Studies at the University of Utah and colleagues examined the firearm storage practices of 1,652 active-duty military personnel who were seen in military primary care clinics between July 2015 and August 2018. They used the Behavioral Risk Factor Surveillance System to ask participants about firearm ownership and defined safe storage as keeping fir...
Source: Psychiatr News - Category: Psychiatry Tags: Craig J. Bryan firearms JAMA Network Open military Patient Health Questionnaire-9 self-harm storage suicidal ideation suicide Source Type: research
Authors: Tao S, Jia M, Qiu T Abstract Expression of Ca2+/CaM-dependent protein kinase II (CaMKII) and connexin 43 (Cx43) in a rat model of post-stroke depression (PSD) was investigated. Rats were separated into control group (10 rats underwent a sham operation and were not ligated after incision), PSD group (13 PSD rats) and KN93 group (12 rats were treated with KN93, an inhibitor of CaMKII, on the basis of the PSD group). After PSD modeling, Longa scoring was performed, and an open field test as well as a step-through test were carried out to observe rat behavior. RT-qPCR and western blot analysis were used to det...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Authors: Petralia MC, Mazzon E, Fagone P, Falzone L, Bramanti P, Nicoletti F, Basile MS Abstract Post-partum depression (PPD) occurs in approximately 20% of women usually early following child delivery. PPD represents an important unmet medical need as it is frequently underdiagnosed and, as the neurobiology of the disease is limitedly known, no pathogenic-tailored approach is available and only symptomatic medications are used. In the present study, we carried out a DNA microarray analysis to evaluate the fluctuation of cytokines, cytokine receptors and chemokines during the preconception period, the 1st and 3th t...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Authors: Gong X, Liu C, Wang H, Fan J, Jiang C, Zou Y Abstract The incidence of depression has previously been correlated to hypertension. The aim of the present study was to explore the mechanisms of depression and hypertension by examining the expression and interaction of renin/prorenin receptor (PRR) and heme oxygenase 1 (HO-1) in vascular endothelial cells. A case-control study was conducted, and general data and serum factors were compared between hypertension patients complicated with depression and patients with hypertension alone. Logistic regression analysis was used to detect risk factors associated with...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Authors: Lu P, Shelley M PMID: 31409091 [PubMed - as supplied by publisher]
Source: International Journal of Aging and Human Development - Category: Geriatrics Tags: Int J Aging Hum Dev Source Type: research
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