Health Tip: Diagnosing Alzheimer's Early

Title: Health Tip: Diagnosing Alzheimer's EarlyCategory: Health NewsCreated: 1/22/2019 12:00:00 AMLast Editorial Review: 1/22/2019 12:00:00 AM
Source: MedicineNet Alzheimer - Category: Geriatrics Source Type: news

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Publication date: Available online 13 July 2019Source: Journal of Herbal MedicineAuthor(s): Swati Vyas, S.L. Kothari, Sumita KachhwahaAbstractWith the rise in the ageing population in the last few decades, dementia has emerged as a serious global health issue. Alzheimer's disease (AD) is the most common type of dementia. Despite extensive drug development research, only a limited number of FDA-approved drugs are available for AD. As these drugs provide symptomatic relief only and are frequently associated with adverse effects, there remains an urgent need for developing alternative approaches to AD therapeutics. Several me...
Source: Journal of Herbal Medicine - Category: Complementary Medicine Source Type: research
There hasn’t been much good news about Alzheimer’s lately, between the March announcement by Biogen and Esai that a promising trial of a potential drug treatment failed, and the July decision by Novartis and Amgen to stop their study of another class of therapies for the neurodegenerative disease. But in a pair of studies presented at the annual Alzheimer’s Association International Conference on July 14, researchers reported encouraging results from studies of non-drug approaches. In one, scientists led by Dr. Klodian Dhana at Rush University Medical Center in Chicago followed nearly 2,500 people for alm...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Alzheimer's Brain embargoed study Source Type: news
This cohort study uses UK Biobank data to examine interactions between polygenic risk for Alzheimer disease and lifestyle (physical activity, healthy diet, moderate alcohol drinking) and their associations with incident all-cause dementia.
Source: JAMA - Journal of the American Medical Association - Category: General Medicine Source Type: research
Authors: Schulz H, Karrasch S, Bölke G, Cyrys J, Hornberg C, Pickford R, Schneider A, Witt C, Hoffmann B Abstract The third part of the DGP statement introduces the current body of knowledge on less studied health outcomes associated with exposure to ambient air pollution: the negative impact on metabolism leading to impaired glucose tolerance and diabetes as well as contribution to the development of neurodegenerative disorders and delayed cognitive function in children. Furthermore, prenatal exposure and adverse effects on mother and child are addressed. Finally, the currently discussed biological mechanisms...
Source: Pneumologie - Category: Respiratory Medicine Tags: Pneumologie Source Type: research
Dear Candid Caregiver: ...I don’t blame Mom because the whole thing is awful, but doing anything that increases Dad’s anxiety is a bad idea for him as well as those around him. The more Mom’s resentment about their failed dreams shows the more anxious and difficult Dad gets. The harder Dad is to care for, the more Mom’s body language and tone of voice show how on edge she is. I’m not perfect, I know, so I’m trying not to judge, but I believe that I have more distance and, for that reason, more clarity, than my mom. How do I approach Mom without upsetting her more than she already is? &nd...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
ConclusionsResults indicate that chemotherapy-induced spatial memory deficits in mice can be prevented, but not reversed by the use of acetylcholinesterase inhibitors concomitant with chemotherapy, suggesting that these agents should be investigated further for the prevention of chemobrain.
Source: Cancer Chemotherapy and Pharmacology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 11 July 2019Source: NeuroscienceAuthor(s): Sylvie L. Lesuis, Paul J. Lucassen, Harm J. KrugersAbstractCognitive deficits and alterations in emotional behaviour are typical features of Alzheimer's disease (AD). Moreover, exposure to stress or adversity during the early life period has been associated with an acceleration of cognitive deficits and increased AD pathology in transgenic AD mouse models. Whether and how early life adversity affects fear memory in AD mice remains elusive.We therefore investigated whether exposure to early life stress (ELS) alters fear learning in APPswe/PS1dE9 m...
Source: Neuroscience - Category: Neuroscience Source Type: research
Amgen and Novartis will abandon work on umibecestat, an experimental BACE inhibitor for Alzheimer's disease, following evidence of worsening cognitive function in a clinical trial.Medscape Medical News
Source: Medscape Psychiatry Headlines - Category: Psychiatry Tags: Psychiatry News Source Type: news
Mentally stimulating activities like using a computer, playing games, crafting, and participating in social activities were associated with a lower risk of mild cognitive impairment in older people, astudy published inNeurology has found. People with mild cognitive impairment, which is not the same as dementia, may have memory loss or have difficulty following conversations or understanding complex information.Janina Krell-Roesch, Ph.D., of Mayo Clinic ’s Translational Neuroscience and Aging Laboratory, and colleagues analyzed five-year data from 2,000 participants in the population-based Mayo Clinic Study of Aging. ...
Source: Psychiatr News - Category: Psychiatry Tags: aging cognition cognitive decline healthy aging memory loss mental stimulation mild cognitive impairment social activities Source Type: research
Conclusion: We believe, therefore, that the available data suggest an important role of the amyloid pore mechanism in the pathogenesis of the Alzheimer's disease, the use of oocytes for its study, and how a moderate consumption of ethanol could reduce the effects of amyloid aggregates.
Source: Current Chemical Biology - Category: Biochemistry Source Type: research
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