Antigenicity, pathogenicity and immunosuppressive effect caused by a South American isolate of infectious bursal disease virus belonging to the 'distinct' genetic lineage.

Antigenicity, pathogenicity and immunosuppressive effect caused by a South American isolate of infectious bursal disease virus belonging to the 'distinct' genetic lineage. Avian Pathol. 2019 Jan 21;:1-31 Authors: Tomás G, Marandino A, Courtillon C, Amelot M, Keita A, Pikula A, Hernández M, Hernández D, Vagnozzi A, Panzera Y, Domańska-Blicharz K, Eterradossi N, Pérez R, Soubies SM Abstract Infectious bursal disease virus (IBDV) is the causative agent of a highly contagious immunosuppressive disease affecting young chickens. The recently described 'distinct IBDV' (dIBDV) genetic lineage encompasses a group of worldwide distributed strains that share conserved genetic characteristics in both genome segments making them unique within IBDV strains. Phenotypic characterization of these strains is scarce and limited to Asiatic and European strains collected more than fifteen years ago. The present study aimed to assess the complete and comprehensive phenotypic characterization of a recently collected South American dIBDV strain (1/chicken/URY/1302/16). Genetic analyses of both partial genome segments confirmed that this strain belongs to the dIBDV genetic lineage and that it is not a reassortant. Antigenic analysis with monoclonal antibodies indicated that this strain has a particular antigenic profile, similar to that obtained in a dIBDV strain from Europe (80/GA), which differs from those previously found in the traditional classi...
Source: Avian Pathology - Category: Pathology Authors: Tags: Avian Pathol Source Type: research

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Source: Proceedings of the National Academy of Sciences - Category: Science Tags: In This Issue This Week in PNAS Source Type: research
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