Treatment of Clozapine Nonresponders

This article attempts to review the available evidence for management of patients with schizophrenia, who do not respond adequately to clozapine and require augmentation of clozapine with another treatment strategy.Recent findingsMany treatment strategies have been evaluated for management of this group of patients. Commonly used pharmacological augmentation strategies which have been evaluated include addition of a second antipsychotic, mood stabilizer, and antidepressant. Other pharmacological agents such as memantine, donepezil, amino acids, omega-3 fatty acids etc. have also been tried. Among the somatic treatments, electroconvulsive therapy (ECT), repetitive transcranial magnetic stimulation (rTMS), and transcranial direct current stimulation (tDCS) have also been evaluated. Non-pharmacological strategies such as cognitive behavior therapy and occupational therapy have also been evaluated clozapine non-response cases. However, at the present, the data is limited to small sample size studies and is not sufficient to make any specific recommendation.SummaryAmong the various strategies evaluated, ECT is possibly the most effective augmentation strategy in patients not responding or partially responding to clozapine. Among the various pharmacological agents, if the target is positive symptoms, then one of the second-generation antipsychotic like amisulpride or aripiprazole may be considered. If the target is negative symptoms, then amisulpride, mirtazapine, lamotrigine, fluv...
Source: Current Treatment Options in Psychiatry - Category: Psychiatry Source Type: research

Related Links:

CONCLUSIONS: The SH staff was able to produce valid FAST-O assessments. There are reference data which makes it possible to characterize individual patients as well as SH units with respect to treatment needs and safety aspects (for instance risk of violence). PMID: 30888234 [PubMed - as supplied by publisher]
Source: Nordic Journal of Psychiatry - Category: Psychiatry Tags: Nord J Psychiatry Source Type: research
Authors: Faivre S, Roche N, Lacerre F, Dealberto MJ Abstract OBJECTIVES: The main objective of the study was to assess 25-hydroxyvitamin D (25(OH)D) status in a psychiatric population in France according to psychiatric diagnoses. The secondary objective was to investigate a correlation between 25(OH)D and CRP. METHODS: A retrospective study from February 1st, 2014 to January 31, 2016, was carried out in a French psychiatric hospital. Inpatients with a 25(OH)D measure were included. Variables including ethnic origin, BMI, psychiatric diagnoses, medical history and CRP were collected. Factors associated with 25(O...
Source: L Encephale - Category: Psychiatry Tags: Encephale Source Type: research
Conditions:   Schizophrenia;   Psychotic Disorders;   Psychosis Interventions:   Drug: Aripiprazole;   Drug: Risperidone Sponsors:   Fundación Marques de Valdecilla;   Centro de Investigación Biomédica en Red de Salud Mental;   Instituto de Investigación Marqués de Valdecilla Enrolling by invitation
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Schizophrenia Intervention:   Behavioral: Calligraphy Sponsors:   The Hong Kong Polytechnic University;   Jianan Psychiatric Center, Ministry of Health and Welfare Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Smoking high-potency cannabis, and daily marijuana use, have been linked to diagnosis of conditions like schizophrenia, paranoia and other psychosis disorders, new findings say.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news
Publication date: Available online 19 March 2019Source: Journal of Neuroscience MethodsAuthor(s): Qingbao Yu, Jiayu Chen, Yuhui Du, Jing Sui, Eswar Damaraju, Jessica A. Turner, Theo G.M. van Erp, Fabio Macciardi, Aysenil Belger, Judith M. Ford, Sarah McEwen, Daniel H. Mathalon, Bryon A. Mueller, Adrian Preda, Jatin Vaidya, Godfrey D. Pearlson, Vince D. CalhounAbstractIt has been widely shown that genomic factors influence both risk for schizophrenia and variation in functional brain connectivity. Moreover, schizophrenia is characterized by disrupted brain connectivity. In this work, we proposed a genome-connectome bipartit...
Source: Journal of Neuroscience Methods - Category: Neuroscience Source Type: research
ORANGEBURG, SC (WRDW/WAGT) - Questions continue to surround the case of a man who was killed while walking down Interstate 95 in Orangeburg County last year. Those questions surround an EMT and a paramedic who treated Paul Tarashuk before he was released from their care and into the care of an Orangeburg County deputy. That deputy dropped Tarashuk off 18 miles away at a closed gas station. The paramedic is allowed to keep working after South Carolina ruled she and the other EMT abandoned Tarashuk instead of taking him to a nearby hospital. It started with a few 911 calls on Sept. 9, 2018. 911 Caller: There is a man naked r...
Source: JEMS: Journal of Emergency Medical Services News - Category: Emergency Medicine Tags: News Patient Care Administration and Leadership Source Type: news
The unnamed 14-year-old boy, from a Midwestern US state, failed to respond to dozens of treatments. It was marks on his skin that led to the discovery of Bartonella, a cat-carried infection.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
CONCLUSIONS: BWISE could be used as a useful screening instrument to assess the psychosocial consequences of weight gain in patients. PMID: 30884381 [PubMed - as supplied by publisher]
Source: Asian Journal of Psychiatry - Category: Psychiatry Tags: Asian J Psychiatr Source Type: research
CONCLUSION: Results indicated differences in semantic processing between BD and SZ. Further studies with larger populations are needed in order to develop neurophysiological markers of these disorders. PMID: 30887935 [PubMed - as supplied by publisher]
Source: Acta Neuropsychiatrica - Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research
More News: Abilify | Cognitive Behavior Therapy | Donepezil | Electroconvulsive Therapy | Lamictal | Mirtazapine | Namenda | Occupational Health | Occupational Therapy | Omega 3 | Psychiatry | Schizophrenia | Study