AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis [Pharmacology]

Onchocerciasis and lymphatic filariasis are two neglected tropical diseases that together affect ∼157 million people and inflict severe disability. Both diseases are caused by parasitic filarial nematodes with elimination efforts constrained by the lack of a safe drug that can kill the adult filaria (macrofilaricide). Previous proof-of-concept human trials have...

Source: Proceedings of the National Academy of Sciences - January 22, 2019 Category: Science Authors: W. David Hong, Farid Benayoud, Gemma L. Nixon, Louise Ford, Kelly L. Johnston, Rachel H. Clare, Andrew Cassidy, Darren A. N. Cook, Amy Siu, Motohiro Shiotani, Peter J. H. Webborn, Stefan Kavanagh, Ghaith Alȷayyoussi, Emma Murphy, Andrew Steven, Joh Tags: Biological Sciences Source Type: research