Neuroprotective Effect of Ilex Paraguariensis Intake on Brain Myelin of Lung Adenocarcinoma-Bearing Male Balb/c Mice.

Neuroprotective Effect of Ilex Paraguariensis Intake on Brain Myelin of Lung Adenocarcinoma-Bearing Male Balb/c Mice. Nutr Cancer. 2019 Jan 19;:1-5 Authors: Cittadini MC, Albrecht C, Miranda AR, Mazzuduli GM, Soria EA, Repossi G Abstract Ilex paraguariensis (IP) is widely consumed as tea with high nutritional value. This plant contains several bioactive phenolic compounds, which are antioxidant and anti-inflammatory. On the other hand, lung adenocarcinoma (LAC) deleteriously involves neoplastic progression, inflammatory paraneoplastic syndromes, and death. Given that brain is a frequent target of this illness, our objective was to determine the neuroprotective effect of IP consumption in LAC-bearing mice. They were orally treated with 50 mg of IP extract/kg/day (IP50) for 3 weeks. Results (phenolic compounds, lipid peroxides, interleukin 6-IL-6-, tumor necrosis factor alpha -TNFα-, and luxol-stained myelination) were compared with respect to untreated controls (C) by the T test. IP50 significantly lowed brain IL-6 (2858.12 ± 57.81 pg g-1 vs. 3801.30 ± 27.34 pg g-1), whereas other variables differed in a less extent. C brains showed demyelination (low luxol-staining contrast between gray and white matters), with IP50 increasing myelination (P 
Source: Nutrition and Cancer - Category: Cancer & Oncology Authors: Tags: Nutr Cancer Source Type: research

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In this study, we used the Megalobrama amblycephala to investigate the effects of G. elegans alkaloids on fish intestinal health after diet supplementation with 0, 5, 10, 20 and 40 mg/kg G. elegans alkaloids for 12 weeks. We found that dietary G. elegans alkaloids at 40 mg/kg improved intestinal morphology by increasing villus length, muscle thickness and villus number in the foregut and midgut and muscle thickness in the hindgut (P 
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
Publication date: Available online 21 September 2019Source: Process BiochemistryAuthor(s): Velusamy Arumugam, Manigandan Venkatesan, Selvakumar Murugesan, Rathinam Ayyasamy, Saravanan Ramachandran, Umamaheswari Sundaresan, Arivalagan PugazhendhiAbstractMarine ascidians contain potential bioactive compounds, which exhibit significant pharmacological activities. In the present study, the MeOH extract of Didemnum sp. was subjected to FT-IR, GC-MS analysis, the possible interactions with EGFR through docking analysis and in vitro cytotoxic activity against KB (Human oral cancer) cell line were also studied. The FT-IR analysis ...
Source: Process Biochemistry - Category: Biochemistry Source Type: research
[Vanguard] As part of ways to reduce the rising spate of cervical cancer cases in the country, Sebeccly Cancer Care organization launched the TimeToScreen 2019 programme on the 19th of September, 2019 at the Zenith House, Iga-Idunganran Primary Healthcare Centre, Iga-Idunganran, Lagos Island.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
ConclusionThose who use other cancer patients’ experiences to aid in their surgical decision-making enjoy a higher satisfaction with their decision.
Source: The American Journal of Surgery - Category: Surgery Source Type: research
Discussion:The case clearly demonstrates poor prognostic indicators with hypercalcemia and severe leukocytosis in the setting of end stage lung adenosquamous carcinoma. Classically, paraneoplastic hypercalcemia is associated with PTHrP production in Squamous Cell carcinoma. Overall incidence of hypercalcemia in lung cancer ranges from to 8%-12% with median survival time (MST) of 3.8 months (1,2).Paraneoplastic Leukocytosis meanwhile is most often associated with adenocarcinoma (42%) and squamous cell carcinoma (36%) with incidence ranging between 16 and 30% and MST of 1.9 months (1,2). Nonetheless, the combination of these...
Source: Blood - Category: Hematology Authors: Tags: 203. Lymphocytes, Lymphocyte Activation, and Immunodeficiency, including HIV and Other Infections Source Type: research
AbstractTo describe autoantibodies (Abs) against tripartite motif-containing (TRIM) protein 9 and 67 in two patients with paraneoplastic cerebellar degeneration (PCD) associated with lung adenocarcinoma. Abs were characterized using immunohistochemistry, Western blotting, cultures of murine cortical, and hippocampal neurons, immunoprecipitation, mass spectrometry, knockout mice forTrim9 and67, and cell-based assay. Control samples included sera from 63 patients with small cell lung cancer without any paraneoplastic neurological syndrome, 36 patients with lung adenocarcinoma and PNS, CSF from 100 patients with autoimmune en...
Source: The Cerebellum - Category: Neurology Source Type: research
Honnorat J Abstract To describe autoantibodies (Abs) against tripartite motif-containing (TRIM) protein 9 and 67 in two patients with paraneoplastic cerebellar degeneration (PCD) associated with lung adenocarcinoma. Abs were characterized using immunohistochemistry, Western blotting, cultures of murine cortical, and hippocampal neurons, immunoprecipitation, mass spectrometry, knockout mice for Trim9 and 67, and cell-based assay. Control samples included sera from 63 patients with small cell lung cancer without any paraneoplastic neurological syndrome, 36 patients with lung adenocarcinoma and PNS, CSF from 100 pat...
Source: Cerebellum - Category: Neuroscience Authors: Tags: Cerebellum Source Type: research
Objective:To report a case of a Japanese woman with a history of AMPA-R antibody positive paraneoplastic limbic encephalitis with non-small cell lung cancer.Background:Limbic encephalitis was first described by Corsellis as degeneration or inflammation of limbic gray matter. It is a rare diagnosis occurring in less than one percent of cancer cases reported by Anderson et al. Alpha-amino-3­-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA-R) is a recently described cell surface autoantigen. Antibodies to AMPA-R is thought to be rare a pathogenic mechanism for patients with paraneoplastic limbic encephalitis.Des...
Source: Neurology - Category: Neurology Authors: Tags: Neurologic Complications of Cancer Source Type: research
Conclusions:This case highlights the importance of CSF studies in diagnosing PND. A review of the literature demonstrates increased sensitivity of CSF compared to serum in PND. To our knowledge, this is the first case of anti-Yo PND characterized by this discrepancy. The reasons for this may include methodological variables, biological factors, or a combination of both. These possibilities will be further explored.Disclosure: Dr. Sabet has nothing to disclose. Dr. Kim has nothing to disclose. Dr. Wichter has nothing to disclose. Dr. Nicholas has nothing to disclose.
Source: Neurology - Category: Neurology Authors: Tags: Neurologic Complications of Cancer Source Type: research
CONCLUSION: From our case, we would like to emphasize that paraneoplastic limbic encephalitis should be considered among the differential diagnosis of rapidly progressive dementia associated with myoclonus, along with other neurodegenerative diseases. Depending on its underlying malignancy, the cognitive impairment may be substantially reversible, despite atrophy of mesial temporal lobes. PMID: 26077183 [PubMed - indexed for MEDLINE]
Source: Acta Neurologica Taiwanica - Category: Neurology Tags: Acta Neurol Taiwan Source Type: research
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