Effect on long term mortality of Human leukocyte Antigen DR matching in heart transplantation

Human Leukocyte Antigen (HLA) matching exerts a protective effect in organ transplantation ensuring better graft function, fewer episodes of rejection, longer graft survival and the possibility of lower immunosuppression.1 –3 However, the precise influence of HLA incompatibility in heart transplants remains to be determined, and prospective HLA matching is seldom achieved. We previously demonstrated that the odds of in-hospital mortality after heart transplantation is greater in the case of DR-mismatch.

Source: Journal of Cardiac Failure - January 22, 2019 Category: Cardiology Authors: Francesco Cacciatore, Cristiano Amarelli, Chiara Sabia, Irene Mattucci, Claudio Marra, Giampaolo Romano, Pasquale Abete, Ciro Maiello, Claudio Napoli Tags: Research Letter Source Type: research