Impulsiveness as a predictor of topiramate response for cocaine use disorder.

CONCLUSION: The results indicate an association between higher within-group impulsiveness and response to topiramate for CUD. The subscore findings may suggest a complex interaction between effectiveness and known cognitive side effects. The finding that trait impulsiveness is associated with treatment response is a promising discovery that may help guide treatment for CUD.
SCIENTIFIC SIGNIFICANCE: This analysis suggests a possible endophenotype based on impulsiveness that can predict treatment response to topiramate. (Am J Addict 2019;XX:1-6).
PMID: 30664303 [PubMed - as supplied by publisher]

Source: American Journal on Addictions - January 21, 2019 Category: Addiction Authors: Blevins D, Wang XQ, Sharma S, Ait-Daoud N Tags: Am J Addict Source Type: research