Vaccine and Chemotherapy Combo Shows Promise for Mesothelioma

Mesothelioma patients showed an impressive immune response to TroVax, a novel cancer vaccine, when it was combined with standard chemotherapy in a recent clinical trial. Researchers from Cardiff University in the United Kingdom conducted the study that was published by the journal OncoImmunology. TroVax is a laboratory engineered virus designed to target the human protein 5T4. A mutated form of 5T4 is found in almost all mesothelioma tumors, including the sarcomatoid subtype, the most difficult to treat. The phase II clinical trial produced a disease control rate of 87 percent, more than double the rate of a previous study done without the vaccine. More than 17 percent of patients saw tumor reduction. “This was a proof-of-concept study, and we proved it. We were able to demonstrate the response,” Angela Casbard, senior research fellow in statistics at Cardiff, told The Mesothelioma Center at Asbestos.com. “We don’t know yet the clinical impact or what it could be.” Vaccine Used with Other Cancers TroVax, which is produced by Oxford BioMedica in the United Kingdom, already has been tested successfully with renal, colorectal and prostate cancers. Treatment-related side effects were comparable to those seen with chemotherapy alone. Of the 23 patients who received at least three doses of TroVax, 22 developed a humoral or cellular immune response. This was well beyond the targeted response rate of 64 percent. All three patients with sarcomatoid meso...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news

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This study aimed to explore whether a correlation exists between the incidence and mortality of cancers and normalized internet search volumes on the big data platform, Baidu. We also assessed whether the distribution of people who searched for specific types of cancer differed by gender. Finally, we determined whether there were regional disparities among people who searched the Web for cancer-related information. Methods: Standard Boolean operators were used to choose search terms for each type of cancer. Spearman’s correlation analysis was used to explore correlations among monthly search index values for each can...
Source: Journal of Medical Internet Research - Category: General Medicine Authors: Source Type: research
Radiation oncologist Dr. Andrea McKee believes deaths from lung cancer — including those related to asbestos exposure — could be reduced significantly by increased utilization of early CT screening. McKee, chair of radiation oncology at Lahey Hospital and Medical Center in Burlington, Maine, has been a strong proponent of early screening for several years. “We could be saving tens of thousands of lives every year with this,” McKee told The Mesothelioma Center at Asbestos.com. “There is nothing else like it. The life-saving potential is the most important thing that has happened to cancer in my...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
Cancer patients who opt for alternative therapy instead of conventional medicine significantly decrease their chances of survival, according to researchers at Yale School of Medicine. Although the popularity of alternative medicine continues to grow, a recent study published in the Journal of the National Cancer Institute found survival rates significantly reduced for those who use it as first-line therapy. Conventional cancer treatments — chemotherapy, surgery and radiation — still produce a much better chance of survival. Mesothelioma was not included in the study, but the findings are relevant to this rare ...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: acupuncture cancer Alternative medicine alternative mesothelioma treatment alternative therapy survival alternative vs conventional medicine breast cancer colon cancer Conventional cancer treatments Dr. David Gorski Dr. Skyler Johnson Source Type: news
Authors: Cappuccini F, Pollock E, Stribbling S, Hill AVS, Redchenko I Abstract The tumour-associated antigen 5T4 is an attractive target for cancer immunotherapy. However to date, reported 5T4-specific cellular immune responses induced by various immunisation platforms have been largely weak or non-existent. In the present study, we have evaluated a heterologous prime boost regime based on the simian adenovirus ChAdOx1 and modified vaccinia virus Ankara (MVA) expressing 5T4 for immunogenicity and tumour protective efficacy in a mouse cancer model. Vaccination-induced immune responses were strong, durable and attrib...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
By Stacy Simon The death rate from cancer in the US has declined steadily over the past 2 decades, according to annual statistics reporting from the American Cancer Society. The cancer death rate for men and women combined fell 25% from its peak in 1991 to 2014, the most recent year for which data are available. This decline translates to more than 2.1 million deaths averted during this time period. “Cancer Statistics, 2017,” published in the American Cancer Society’s journal CA: A Cancer Journal for Clinicians, estimates the numbers of new cancer cases and deaths expected in the US this year. The estimat...
Source: American Cancer Society :: News and Features - Category: Cancer & Oncology Tags: General Information Source Type: news
Thoracic surgeon Dr. Raja Flores, like so many other patriotic Americans, rushed to help after the horrific 9/11 terrorist attack at the World Trade Center (WTC) in New York City. As the world prepares to commemorate the 15th anniversary of the 9/11 attacks, Flores’ work is far from done. While the memory of that fateful Sept. 11, 2001, is beginning to fade for many, the threat of a resulting and significant rise in mesothelioma cancer is looming large on the horizon. The alarming number of future mesothelioma cases will stem from the weeks-long rescue and cleanup efforts performed under the toxic cloud that containe...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: 15th anniversary 9/11 9/11 15 year anniversary 9/11 attack at world trade center 9/11 mesothelioma cases 9/11 terrorist attack asbestos after 9/11 attack asbestos in 9/11 attack Source Type: news
Thoracic surgeon and robotics innovator Dr. Farid Gharagozloo believes regular early screenings and better follow-up care will significantly reduce the annual number of Americans dying of lung cancer by almost two-thirds. Gharagozloo, director of cardiothoracic surgery at Florida Hospital Celebration Health, says the medical establishment in the U.S. and patients themselves share the blame for the unreasonably high number of lung cancer deaths today. Patients need to be more assertive. Doctors need to be more aggressive. Together, they can make a big difference. "We can turn this thing around — change the who...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: Treatment & Doctors Source Type: news
MicroRNA expression is commonly suppressed in cancer, contributing to tumor cell biology. Recently we demonstrated that multiple members of the miR-15/16 family are downregulated and have tumor suppressor functions in malignant pleural mesothelioma (MPM), an asbestos-related cancer for which few treatments are available. These results are similar to previous findings in prostate and non-small cell lung cancer (NSCLC). Using mimics to restore levels of miR 15a, miR-15b or miR-16 led to growth inhibition and induction of apoptosis of MPM cells in vitro. The miR-16 mimic, packaged in bacterially-derived, EGFR antibody-targete...
Source: Cancer Research - Category: Cancer & Oncology Authors: Tags: Molecular and Cellular Biology Source Type: research
Publication date: 20 July 2015 Source:Clinica Chimica Acta, Volume 447 Author(s): Bin Wei , Chunmei Guo , Shuqing Liu , Ming-Zhong Sun Annexin A4 (Anxa4) is one of the Ca2+-regulated and phospholipid-binding annexin superfamily proteins. Anxa4 has a potential role in diagnosis, prognosis, and treatment of certain cancers. Studies indicate that Anxa4 up-regulation promotes the progression of tumor and chemoresistance of colorectal cancer (CRC), esophageal squamous cell carcinoma (ESCC), endometrial carcinoma (EC), gastric cancer (GC), chemoresistant lung cancer (LC), malignant mesothelioma (MM), renal cell carcinoma (RCC)...
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
Abstract Annexin A4 (Anxa4) is one of the Ca(2+)-regulated and phospholipid-binding annexin superfamily proteins. Anxa4 has a potential role in diagnosis, prognosis and treatment of certain cancers. Studies indicate that Anxa4 up-regulation promotes the progression of tumor and chemo-resistance of colorectal cancer (CRC), esophageal squamous cell carcinoma (ESCC), endometrial carcinoma (EC), gastric cancer (GC), chemo-resistant lung cancer (LC), malignant mesothelioma (MM), renal cell carcinoma (RCC), ovarian clear cell carcinoma (OCCC), cholangiocarcinoma, hepatocellular carcinoma (HCC), breast cancer (BC) and la...
Source: International Journal of Clinical Chemistry - Category: Chemistry Authors: Tags: Clin Chim Acta Source Type: research
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