Optimization techniques for novel c-Met kinase inhibitors

Volume 14, Issue 1, January 2019, Page 59-69 .
Source: Expert Opinion on Drug Discovery - Category: Drugs & Pharmacology Authors: Source Type: research

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Publication date: 1 July 2020Source: Advances in Space Research, Volume 66, Issue 1Author(s):
Source: Advances in Space Research - Category: Science Source Type: research
Publication date: 1 July 2020Source: Advances in Space Research, Volume 66, Issue 1Author(s): Loren C. Chang, Amal Chandran
Source: Advances in Space Research - Category: Science Source Type: research
Publication date: 1 July 2020Source: Advances in Space Research, Volume 66, Issue 1Author(s):
Source: Advances in Space Research - Category: Science Source Type: research
AbstractSevere and recurrent infections of the respiratory tract in early childhood constitute major risk factors for the development of bronchial hyper-responsiveness and obstructive respiratory diseases in later life. In the first years of life, the vast majority of respiratory tract infections (RTI) leading to wheezing and asthma are of a viral origin and severity and recurrence are the consequence of a greater exposure to infectious agents in a period when the immune system is still relatively immature. Therefore, boosting the efficiency of the host immune response against viral infections seems to be a rational preven...
Source: Clinical and Translational Allergy - Category: Allergy & Immunology Source Type: research
Authors: Merriman-Nai S, Stein KF Abstract Friends and colleagues describe the legacy of and pay tribute to Lori Stiegel, elder justice champion, who died earlier this year. PMID: 32456595 [PubMed - as supplied by publisher]
Source: Journal of Elder Abuse and Neglect - Category: Geriatrics Tags: J Elder Abuse Negl Source Type: research
This study includes the measures of self-reported PA (International Physical Activity Questionnaire) and self-rated vision at three points in time over a 6-year period used in the Irish Longitudinal study of Ageing, a cohort of community-dwelling older adults (50 years or older). A path analysis found that PA was indirectly associated with vision over 6 years controlling for age, sex, marital status, employment, education, depression (Centre for Epidemiologic Studies Depression Scale), self-reported general health, cardiovascular disease (e.g., heart attack), high blood pressure, diabetes, eye disease (e.g., glau...
Source: Journal of Aging and Physical Activity - Category: Geriatrics Tags: J Aging Phys Act Source Type: research
The ever-promising opportunities and the uses of NP in our life are increasing but their present and future potential risks on the animals, plants and microorganisms are not well discussed elsewhere. In this review, the authors have systematically discussed the toxic effect of the uses of NP on animals, plants and microorganisms including human health. They have also discussed about the bioaccumulation of these NP in the food chain. Finally, they have provided some possible suggestions for the uses of NP to reduce the detrimental effect on the environment.
Source: IET Nanobiotechnology - Category: Nanotechnology Source Type: research
The present study aimed to develop a surface-modified biocompatible nanostructured lipid carrier (NLCs) system using polyoxyethylene (40) stearate (POE-40-S) to improve the oral bioavailability of poorly water-soluble Biopharmaceutics Classification System class-II drug like tamoxifen (TMX). Also aimed to screen the most influential factors affecting the particle size (PS) using Taguchi (L12 (211)) orthogonal array design (TgL12OA). Then, to optimize the TMX loaded POE-40-S (P) surface-modified NLCs (TMX-loaded-PEG-40-S coated NLC (PNLCs) or PNLCs) by central composite design (CCD) using a four-factor, five-level model. Th...
Source: IET Nanobiotechnology - Category: Nanotechnology Source Type: research
In this study, facile synthesis of magnetic iron oxide–tea waste nanocomposite is reported for adsorptive removal of lead ions from aqueous solutions and easy magnetic separation of the adsorbent afterwards. The samples were characterised by scanning electron microscopy, Fourier transform-infrared spectroscopy, X-ray diffraction, and Braunner–Emmet–Teller nitrogen adsorption study. Adsorptive removal of Pb(II) ions from aqueous solution was followed by ultraviolet–visible (UV–Vis) spectrophotometry. About 95% Pb(II) ion removal is achieved with the magnetic tea waste within 10 min. A coeffic...
Source: IET Nanobiotechnology - Category: Nanotechnology Source Type: research
Chinese sturgeon (Acipenser sinensis) fish skin is an excellent natural material with remarkable mechanical properties owing to the unique structures of the helical stacking fibres. In this work, the authors studied the potential role of the sturgeon fish skin in the protective function through testing and analysed the structural features and mechanical properties of the stratum compactum in the fish skin. Scanning electron microscopy images of the sturgeon fish skin revealed that the skin was primarily composed of the stratum compactum. The stratum compactum was characterised by the helically arranged fibre structures and...
Source: IET Nanobiotechnology - Category: Nanotechnology Source Type: research
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