Cancers, Vol. 11, Pages 124: Detection of TP53 Mutations in Tissue or Liquid Rebiopsies at Progression Identifies ALK+ Lung Cancer Patients with Poor Survival
Cancers, Vol. 11, Pages 124: Detection of TP53 Mutations in Tissue or Liquid Rebiopsies at Progression Identifies ALK+ Lung Cancer Patients with Poor Survival
Cancers doi: 10.3390/cancers11010124
Authors:
Petros Christopoulos
Steffen Dietz
Martina Kirchner
Anna-Lena Volckmar
Volker Endris
Olaf Neumann
Simon Ogrodnik
Claus-Peter Heussel
Felix J. Herth
Martin Eichhorn
Michael Meister
Jan Budczies
Michael Allgäuer
Jonas Leichsenring
Tomasz Zemojtel
Helge Bischoff
Peter Schirmacher
Michael Thomas
Holger Sültmann
Albrecht Stenzinger
Anaplastic lymphoma kinase (ALK) sequencing can identify resistance mechanisms and guide next-line therapy in ALK+ non-small-cell lung cancer (NSCLC), but the clinical significance of other rebiopsy findings remains unclear. We analysed all stage-IV ALK+ NSCLC patients with longitudinally assessable TP53 status treated in our institutions (n = 62). Patients with TP53 mutations at baseline (TP53mutbas, n = 23) had worse overall survival (OS) than patients with initially wild-type tumours (TP53wtbas, n = 39, 44 vs. 62 months in median, p = 0.018). Within the generally favourable TP53wtbas group, detection of TP53 mutations at progression defined a “converted” subgroup (TP53mutconv, n = 9) with inferior OS, similar to that of TP53mutbas and shorter than that of patients remaining TP53 wild-type (TP53wtprogr, 45 vs. 94 months, p = 0.043). Progression-free survival (PFS) under treatment with tyrosine kinas...
Source: Cancers - Category: Cancer & Oncology Authors: Petros Christopoulos Steffen Dietz Martina Kirchner Anna-Lena Volckmar Volker Endris Olaf Neumann Simon Ogrodnik Claus-Peter Heussel Felix J. Herth Martin Eichhorn Michael Meister Jan Budczies Michael Allg äuer Jonas Leichsenring Tomasz Zemojtel Helge Bi Tags: Article Source Type: research
More News: Cancer | Cancer & Oncology | Lung Cancer | Lymphoma | Non-Small Cell Lung Cancer | Nutrition