Increase in pharmacodynamic tolerance after repeated antidepressant trials in treatment-responsive bipolar I depressed subjects: An exploratory study.

Conclusion. These results confirm prior observations of an increased pharmacodynamic tolerance after repeated antidepressant administration, resulting in a step-wise loss of antidepressant effectiveness over the course of the illness. PMID: 30659559 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/30659559?dopt=Abstract

Source: Psychiatria Polska - January 21, 2019 Category: Psychiatry Tags: Psychiatr Pol Source Type: research