Genetic Big Data: What It Means

Researchers finished the first draft of the human genome in the year 2000. Although the decreasing cost of the technology has far outpaced Moore’s Law since then, we have yet to fully leverage all that new information to make it really useful. In a wide ranging talk on his work, from transcribing the first complete human genome to building synthetic life forms, genomic pioneer Craig Venter confessed he was disappointed that genomics has taken as long as it has to scale up. “We just got to the starting line,” Venter said, speaking at Singularity University’s Exponential Medicine conference. “Hopefully it won’t take as long to get through it as it took to get started.” What’s changed? Earlier this year, genomic sequencing company, Illumina, announced a new sequencing system that can produce 18,000 high quality human genomes per year at $1,000 per genome -- a mark dreamed of for over a decade. Venter’s new venture, Human Longevity, Inc., purchased two of Illumina’s new sequencers with the aim of ramping up to some 40,000 genomes a year. When asked what’s coming in the next five years, Venter quipped that predicting the future is hard unless you’re an investor, but he thinks a big acceleration is in the cards. “[We’re going to go] from zero to a thousand miles an hour very quickly.” Whereas we’ve sequenced around 225,000 genomes worldwide to date, Venter estimates we’ll h...
Source: Science - The Huffington Post - Category: Science Source Type: news

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“Are you sure she needs this surgery?” my brother asked my surgeon minutes before the doctor entered the operating room. My brother was suspicious of Western medicine’s harsh approaches to treating cancer. “If she doesn’t have this surgery, she’ll be dead in three months,” the surgeon said sternly, put out that my brother would even question his authority. I would learn of this conversation several days after my operation to remove an angiosarcoma on my right breast. The angiosarcoma had resulted from radiation treatment I’d had to eliminate another breast cancer four years b...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Agitation Bipolar Celebrities Depression Suicide Bipolar Disorder Depressive Episode kate spade Source Type: blogs
Listen to part two of the episode recorded live on location at HealtheVoices 2018. (Part one was posted last week, so check it out if you haven’t, already.) In this continuation of the multi-advocate panel discussion, our panelists talk about the most difficult aspect of their advocacy and how they deal with it. They also address misconceptions and ignorance about their diseases, such as the difference between AIDS and HIV or IBD and IBS, the fact that lupus is not contagious, and that men can have breast cancer. To close out the episode, each panelist shares his/her thoughts on what advocates for different condition...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: General Interview Mental Health and Wellness The Psych Central Show Advocacy Source Type: blogs
Listen to part one of the first ever LIVE Psych Central Show, recorded on location at HealtheVoices 2018, an annual event that brings together online advocates from across various health conditions for an opportunity to learn, share and connect. In this show, you will meet four advocates who join our hosts on stage for a panel discussion on a variety of advocacy issues, including lupus, inflammatory bowel disease, HIV, and breast cancer. You’ll hear about how being diagnosed affected their lives in ways they didn’t expect, and what made them become advocates. The second half of this show will be posted next wee...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: General Interview Mental Health and Wellness The Psych Central Show Advocacy Source Type: blogs
ConclusionBreast cancer patients with mental illness should be closely managed by a cross-functional care team, including a psychiatrist, a primary care physician, and an oncologist, to ensure adequate care is received within an appropriate timeframe.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
Tracy Thompson begins her thoughtful book The Ghost in the House with two brilliant sentences: “Motherhood and depression are two countries with a long common border. The terrain is chilly and inhospitable, and when mothers speak of it at all, it is usually in guarded terms, or in euphemisms.” If depression happened in a vacuum, it would be so much easier. But it doesn’t. It happens in the context of a family, raising kids, being responsible for other human beings even as you can’t take care of yourself. My Worst Fear for My Children “Even when it is relatively mild, depression may cause ...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Bipolar Books Brain and Behavior Depression Parenting Personal Source Type: blogs
"For every complex problem there is an answer that is clear, simple, and wrong." H. L. Mencken The nature/nurture debate on the causes of mental disorder generates no end of silly controversy by proponents on both sides. The biological reductionists act like the secret of psychiatric disorders is written in the genetic code. They are "mindless"- dismissing the crucial role of environment in how our brain develops and of psychology and social context in how it functions. The environmental reductionists go to the opposite "brainless" extreme- argueing that a psychiatric disorder is a direct r...
Source: Science - The Huffington Post - Category: Science Source Type: news
The approval of first-of-a-kind drugs rose last year to forty-one, resulting in the highest level of newly approved U.S. drugs in nineteen years. The total number of new drugs approved last year was even higher at sixty-nine. The rising figures reflect an industry-wide desire to research and develop drugs for rare and hard-to-treat diseases. The newly approved drugs serve to advance medical care and the health of patients suffering from many ailments, including various forms of cancer, heart failure, and cystic fibrosis. Additionally, more than 40% of the new therapies were approved for treatment of rare or "orphan&...
Source: Policy and Medicine - Category: American Health Authors: Source Type: blogs
This study aimed to determine whether depression or bipolar recorded in routine hospital admission data independently predicts survival in English breast cancer patients and whether onset in relation to cancer diagnosis is significant. MethodsData on 77 173 women diagnosed with breast cancer (ICD‐10 C50) in South East England, 2000–2009, were included. Of these, 131 women had a diagnosis of bipolar affective disorder (ICD‐10 F31) and 955 of depression (either depressive episodes (ICD‐10 F32) or depressive disorder (ICD‐10 F33)) recorded in Hospital Episode Statistics between 3 years before and a yea...
Source: Psycho-Oncology - Category: Cancer & Oncology Authors: Tags: Paper Source Type: research
Our daughter celebrates her birthday each June. I can't help but measure her birthdays with an equal sense of apprehension and elation. She's a teenager now, and still no sign of the brooding, the polarity, the darkness that descended on my husband like Portland's thick gray clouds in January, refusing to budge. Yes, she has his intellect but she also has my relatively sunny nature. She is physically stunning with long, muscular legs and a waist that defies her voracious appetite. She has David's European cheekbones. The color of her skin is his. Her ears have the same shape. There are times I find myself staring at one of...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
The stress hormone cortisol exhibits a diurnal rhythm throughout the day, as well as within person variability. Recent statistical approaches allow for the estimation of intraindividual cortisol variability (“ICV”) and a greater ICV has been observed in some mood disorders (major depression, remitted bipolar disorder); however, ICV has not been examined following stress management. In this secondary analyses of an efficacious randomized clinical trial, we examine how ICV may change after cognitive behavioral stress management (CBSM) among healthy stressed women at risk for breast cancer.
Source: Journal of Psychosomatic Research - Category: Psychiatry & Psychology Authors: Source Type: research
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