Hormonal medication in medically assisted reproduction: a systematic review of assessments from patients

Publication date: Available online 19 January 2019Source: Reproductive BioMedicine OnlineAuthor(s): Kay Lankreijer, Thomas M D'Hooghe, Silke Apers, Walter Sermeus, Sjoerd Repping, Eline AF DancetAbstractSeveral hormonal fertility medications have comparable effectiveness. A literature review was conducted into patients’ assessments regarding seven medication characteristics including ‘side effects’ and ‘ease of use’. Medline, CINAHL and PsycINFO were searched for female fertility patients’ written assessments of a hormonal medication. The tools used were appraised and common (i.e. ≥10%) unpleasant consequences were distinguished from rare ones. The 35 eligible studies did not rely on valid and reliable tools and did not provide patient assessments regarding all seven medication characteristics for any of the globally used medications. Evidence on medications for oocyte triggering was absent and for induction of pituitary quiescence it was scarce. Regarding medications for ovarian stimulation and luteal support, evidence on general side effects (mostly headache), local side effects (mostly pain), ‘interference with home life’ and ‘impact on psychological wellbeing’ was found. Evidence on ‘ease of use’ and ‘required education’ was only identified for medication for ovarian stimulation. Evidence on ‘interference with work life’ and ‘compliance worry’ was absent. This review calls for randomized controlled trials questioning patients with val...
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research