Viruses, Vol. 11, Pages 84: Meta-Analysis of Human IgG anti-HEV Seroprevalence in Industrialized Countries and a Review of Literature
Viruses, Vol. 11, Pages 84: Meta-Analysis of Human IgG anti-HEV Seroprevalence in Industrialized Countries and a Review of Literature
Viruses doi: 10.3390/v11010084
Authors:
Lisandru Capai
Alessandra Falchi
Rémi Charrel
Although Hepatitis E is increasingly described as a major cause of liver disease in industrialized countries, the epidemiology is far from being fully elucidated. We provide here a comprehensive review of documented clusters of cases, and of serological studies conducted in populations with distinct types of exposure. Seroprevalence rates range from <5% to >50% depending on the countries and the groups of population. Such discrepancies can be attributed to the type of serological assay used, but this solves only a part of the problem. We performed a meta-analysis of studies performed with the broadly used Wantai HEV-IgG ELISA and found striking differences that remain difficult to understand with the current knowledge of transmission pathways.
Source: Viruses - Category: Virology Authors: Lisandru Capai Alessandra Falchi R émi Charrel Tags: Review Source Type: research
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