Thyroid abnormalities in patients with extreme insulin resistance syndromes.

Conclusion: Children with extreme insulin resistance had high prevalence of thyroid nodules, which were not associated with metreleptin treatment. Patients with homozygous INSR mutation had thyromegaly, which may be a novel phenotypic feature of this disease. Further studies are needed to determine the etiology of thyroid abnormalities in patients with extreme insulin resistance.
PMID: 30657911 [PubMed - as supplied by publisher]

Source: The Journal of Clinical Endocrinology and Metabolism - January 16, 2019 Category: Endocrinology Authors: Kushchayeva Y, Kushchayev S, Startzell M, Cochran E, Auh S, Dai Y, Lightbourne M, Skarulis M, Brown R Tags: J Clin Endocrinol Metab Source Type: research