Influence of oral magnesium-containing supplement and antacid administration on hypomagnesemia induced by panitumumab

ConclusionThe use of oral magnesium-containing supplement might function as magnesium supplement based on the finding that use of oral magnesium-containing supplement during panitumumab administration decreased hypomagnesemia. However, combination of antacid decreased the supplemental effect of oral magnesium on hypomagnesemia. These results suggest the possibility that use of antacids during anti-EGFR antibody administration may promote hypomagnesemia.

http://link.springer.com/10.1007/s00280-019-03772-y

Source: Cancer Chemotherapy and Pharmacology - January 19, 2019 Category: Cancer & Oncology Source Type: research