Markers for the Study of Diabetic Neuropathy

Widely Used and Frequently PublishedOurPain and Inflammation Research Antibodies have proven valuable for the study of neuropathic, nociceptive and inflammatory pain.This recent publication is focused on Diabetic Neuropathy. Jos é Eduardo Roa-Coria, Jorge Baruch Pineda-Farias, Paulino Barragán-Iglesias, Geovanna Nallely Quiñonez-Bastidas, Ángel Zúñiga-Romero, Juan Carlos Huerta-Cruz, Juan Gerardo Reyes-García, Francisco Javier Flores-Murrieta, Vinicio Granados-SotoView ORCID ID profile and Héctor Isaac Rocha-Gonzál ez (2019).Possible involvement of peripheral TRP channels in the hydrogen sulfide-induced hyperalgesia in diabetic rats. BMC Neuroscience 201920:1 https://doi.org/10.1186/s12868-018-0483-3.The results show Hydrogen Sulfide (H2S) catalyzes hyperalgesia in rats via TRP Channels. OurSubstance P is used in the study.Figure: Immunolocalization of cystathionin- β-synthase enzyme (CBS, red) with a–e neuronal nuclear antigen (NeuN)-, f–j substance P (SP)-, k–o isolectin B4 (IB4)- and p–t glial fibrillary acidic protein (GFAP)-positive dorsal root ganglion neurons of diabetic rats (green). a, f, k and p show a representative 16 µm-slice from dorsal root ganglia. b, g, l and q show a representative CBS staining with Cy3 from dorsal root neurons, whereas c, h, m and r show NeuN, SP, IB4 and GFAP representative staining with Cy2 in dorsal root neurons, respectively. d, i, n and s show the merged image from Cy3 and Cy2 signals, the overlapping bet ween C...
Source: Neuromics - Category: Neuroscience Tags: Diabetic Neuropathy Hydrogen Sulfide Substance P TRP antibody Source Type: news