Adipocyte GR inhibits healthy adipose expansion through multiple mechanisms in Cushing's syndrome.

In this study, using clinical samples from patients with Cushing's syndrome and adipocyte-specific Gr knockout mice (AGRKO), we investigated the roles of adipocyte GR and its clinical relevance in Cushing's syndrome. Under chronic treatment with corticosterone, AGRKO underwent healthy adipose expansion with diminished ectopic lipid deposition and improved insulin sensitivity. These changes were associated with Atgl-mediated lipolysis through novel intronic glucocorticoid-responsive element. In addition, integrated analysis with RNA-Seq of AGRKO and clinical samples revealed that healthy adipose expansion associated with dysregulation of tissue remodeling, preadipocyte proliferation and expression of circadian gene. Thus, our study unveiled the novel roles of adipocyte GR on healthy adipose expansion and its multiple mechanisms in Cushing's syndrome.
PMID: 30649271 [PubMed - as supplied by publisher]

Source: Endocrinology - January 15, 2019 Category: Endocrinology Authors: Hayashi R, Okuno Y, Mukai K, Kitamura T, Hayakawa T, Onodera T, Murata M, Fukuhara A, Imamura R, Miyagawa Y, Nonomura N, Otsuki M, Shimomura I Tags: Endocrinology Source Type: research